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Fusion gene ID: 5051 |
FusionGeneSummary for C6orf203_BEND3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C6orf203_BEND3 | Fusion gene ID: 5051 | Hgene | Tgene | Gene symbol | C6orf203 | BEND3 | Gene ID | 51250 | 57673 |
| Gene name | chromosome 6 open reading frame 203 | BEN domain containing 3 | |
| Synonyms | HSPC230|PRED31 | KIAA1553 | |
| Cytomap | 6q21 | 6q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | uncharacterized protein C6orf203 | BEN domain-containing protein 3 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9P0P8 | Q5T5X7 | |
| Ensembl transtripts involved in fusion gene | ENST00000405204, ENST00000443043, ENST00000311381, ENST00000489790, | ENST00000369042, ENST00000429433, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 5 X 2 X 4=40 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: C6orf203 [Title/Abstract] AND BEND3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BEND3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21914818 |
| Tgene | BEND3 | GO:0034773 | histone H4-K20 trimethylation | 26100909 |
| Tgene | BEND3 | GO:0036124 | histone H3-K9 trimethylation | 26100909 |
| Tgene | BEND3 | GO:0043967 | histone H4 acetylation | 26100909 |
| Tgene | BEND3 | GO:0051260 | protein homooligomerization | 28977671 |
| Tgene | BEND3 | GO:0098532 | histone H3-K27 trimethylation | 26100909 |
| Tgene | BEND3 | GO:1903580 | positive regulation of ATP metabolic process | 28977671 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A1FE-01A | C6orf203 | chr6 | 107361434 | + | BEND3 | chr6 | 107392154 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000405204 | ENST00000369042 | C6orf203 | chr6 | 107361434 | + | BEND3 | chr6 | 107392154 | - |
| Frame-shift | ENST00000405204 | ENST00000429433 | C6orf203 | chr6 | 107361434 | + | BEND3 | chr6 | 107392154 | - |
| Frame-shift | ENST00000443043 | ENST00000369042 | C6orf203 | chr6 | 107361434 | + | BEND3 | chr6 | 107392154 | - |
| Frame-shift | ENST00000443043 | ENST00000429433 | C6orf203 | chr6 | 107361434 | + | BEND3 | chr6 | 107392154 | - |
| Frame-shift | ENST00000311381 | ENST00000369042 | C6orf203 | chr6 | 107361434 | + | BEND3 | chr6 | 107392154 | - |
| Frame-shift | ENST00000311381 | ENST00000429433 | C6orf203 | chr6 | 107361434 | + | BEND3 | chr6 | 107392154 | - |
| 3UTR-3CDS | ENST00000489790 | ENST00000369042 | C6orf203 | chr6 | 107361434 | + | BEND3 | chr6 | 107392154 | - |
| 3UTR-3CDS | ENST00000489790 | ENST00000429433 | C6orf203 | chr6 | 107361434 | + | BEND3 | chr6 | 107392154 | - |
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FusionProtFeatures for C6orf203_BEND3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C6orf203 | BEND3 |