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Fusion gene ID: 4982 |
FusionGeneSummary for C3_SCAMP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C3_SCAMP2 | Fusion gene ID: 4982 | Hgene | Tgene | Gene symbol | C3 | SCAMP2 | Gene ID | 718 | 10066 |
| Gene name | complement C3 | secretory carrier membrane protein 2 | |
| Synonyms | AHUS5|ARMD9|ASP|C3a|C3b|CPAMD1|HEL-S-62p | - | |
| Cytomap | 19p13.3 | 15q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | complement C3C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1C3a anaphylatoxinacylation-stimulating protein cleavage productcomplement component 3complement component C3acomplement component C3bepididymis secretory sperm binding pr | secretory carrier-associated membrane protein 2testis secretory sperm-binding protein Li 219p | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P01024 | O15127 | |
| Ensembl transtripts involved in fusion gene | ENST00000245907, ENST00000599668, | ENST00000268099, | |
| Fusion gene scores | * DoF score | 20 X 13 X 8=2080 | 5 X 4 X 4=80 |
| # samples | 21 | 5 | |
| ** MAII score | log2(21/2080*10)=-3.30812229536233 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: C3 [Title/Abstract] AND SCAMP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | C3 | GO:0001934 | positive regulation of protein phosphorylation | 15833747 |
| Hgene | C3 | GO:0010575 | positive regulation of vascular endothelial growth factor production | 16452172 |
| Hgene | C3 | GO:0010828 | positive regulation of glucose transmembrane transport | 9059512|15833747 |
| Hgene | C3 | GO:0010866 | regulation of triglyceride biosynthetic process | 10432298 |
| Hgene | C3 | GO:0010884 | positive regulation of lipid storage | 9555951 |
| Hgene | C3 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway | 15833747 |
| Tgene | SCAMP2 | GO:0015031 | protein transport | 15840657 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA699990 | C3 | chr19 | 6677901 | + | SCAMP2 | chr15 | 75146171 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000245907 | ENST00000268099 | C3 | chr19 | 6677901 | + | SCAMP2 | chr15 | 75146171 | + |
| intron-intron | ENST00000599668 | ENST00000268099 | C3 | chr19 | 6677901 | + | SCAMP2 | chr15 | 75146171 | + |
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FusionProtFeatures for C3_SCAMP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C3 | SCAMP2 |