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Fusion gene ID: 4969

FusionGeneSummary for C3_ALB

Fusion gene summary

Fusion gene information	Fusion gene name: C3_ALB
	Fusion gene ID: 4969
		Hgene	Tgene
	Gene symbol	C3	ALB
	Gene ID	718	213
	Gene name	complement C3	albumin
	Synonyms	AHUS5\|ARMD9\|ASP\|C3a\|C3b\|CPAMD1\|HEL-S-62p	HSA\|PRO0883\|PRO0903\|PRO1341
	Cytomap	19p13.3	4q13.3
	Type of gene	protein-coding	protein-coding
	Description	complement C3C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1C3a anaphylatoxinacylation-stimulating protein cleavage productcomplement component 3complement component C3acomplement component C3bepididymis secretory sperm binding pr	serum albumin
	Modification date	20180519	20180522
	UniProtAcc	P01024	P02768
	Ensembl transtripts involved in fusion gene	ENST00000245907, ENST00000599668,	ENST00000295897, ENST00000415165, ENST00000503124, ENST00000509063, ENST00000401494, ENST00000505649,
Fusion gene scores	* DoF score	20 X 13 X 8=2080	27 X 26 X 2=1404
	# samples	21	33
	** MAII score	log2(21/2080*10)=-3.30812229536233 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(33/1404*10)=-2.08900500605874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: C3 [Title/Abstract] AND ALB [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	C3	GO:0001934	positive regulation of protein phosphorylation	15833747
Hgene	C3	GO:0010575	positive regulation of vascular endothelial growth factor production	16452172
Hgene	C3	GO:0010828	positive regulation of glucose transmembrane transport	9059512\|15833747
Hgene	C3	GO:0010866	regulation of triglyceride biosynthetic process	10432298
Hgene	C3	GO:0010884	positive regulation of lipid storage	9555951
Hgene	C3	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway	15833747
Tgene	ALB	GO:0009267	cellular response to starvation	16245148
Tgene	ALB	GO:0019836	hemolysis by symbiont of host erythrocytes	16394536
Tgene	ALB	GO:0043066	negative regulation of apoptotic process	16153637
Tgene	ALB	GO:0051659	maintenance of mitochondrion location	16153637

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AI305112	C3	chr19	6682029	+	ALB	chr4	74270017	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-5UTR	ENST00000245907	ENST00000295897	C3	chr19	6682029	+	ALB	chr4	74270017	+
intron-5UTR	ENST00000245907	ENST00000415165	C3	chr19	6682029	+	ALB	chr4	74270017	+
intron-5UTR	ENST00000245907	ENST00000503124	C3	chr19	6682029	+	ALB	chr4	74270017	+
intron-5UTR	ENST00000245907	ENST00000509063	C3	chr19	6682029	+	ALB	chr4	74270017	+
intron-intron	ENST00000245907	ENST00000401494	C3	chr19	6682029	+	ALB	chr4	74270017	+
intron-intron	ENST00000245907	ENST00000505649	C3	chr19	6682029	+	ALB	chr4	74270017	+
intron-5UTR	ENST00000599668	ENST00000295897	C3	chr19	6682029	+	ALB	chr4	74270017	+
intron-5UTR	ENST00000599668	ENST00000415165	C3	chr19	6682029	+	ALB	chr4	74270017	+
intron-5UTR	ENST00000599668	ENST00000503124	C3	chr19	6682029	+	ALB	chr4	74270017	+
intron-5UTR	ENST00000599668	ENST00000509063	C3	chr19	6682029	+	ALB	chr4	74270017	+
intron-intron	ENST00000599668	ENST00000401494	C3	chr19	6682029	+	ALB	chr4	74270017	+
intron-intron	ENST00000599668	ENST00000505649	C3	chr19	6682029	+	ALB	chr4	74270017	+

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FusionProtFeatures for C3_ALB

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
C3 P01024	ALB P02768

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Fusion gene ID: 4969

FusionGeneSummary for C3_ALB

FusionProtFeatures for C3_ALB