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Fusion gene ID: 4933 |
FusionGeneSummary for C2CD3_PC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C2CD3_PC | Fusion gene ID: 4933 | Hgene | Tgene | Gene symbol | C2CD3 | PC | Gene ID | 26005 | 5420 |
| Gene name | C2 calcium dependent domain containing 3 | podocalyxin like | |
| Synonyms | OFD14 | Gp200|PC|PCLP|PCLP-1 | |
| Cytomap | 11q13.4 | 7q32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | C2 domain-containing protein 3 | podocalyxinGCTM-2 antigenpodocalyxin-like protein 1 | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q4AC94 | P11498 | |
| Ensembl transtripts involved in fusion gene | ENST00000334126, ENST00000313663, ENST00000542452, ENST00000539061, | ENST00000393958, ENST00000393960, ENST00000355677, ENST00000524491, ENST00000529047, ENST00000393955, ENST00000528224, | |
| Fusion gene scores | * DoF score | 13 X 11 X 8=1144 | 9 X 5 X 7=315 |
| # samples | 14 | 9 | |
| ** MAII score | log2(14/1144*10)=-3.03058831983342 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: C2CD3 [Title/Abstract] AND PC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | C2CD3 | GO:0061511 | centriole elongation | 24997988 |
| Hgene | C2CD3 | GO:0071539 | protein localization to centrosome | 24997988 |
| Tgene | PC | GO:0030335 | positive regulation of cell migration | 18456258 |
| Tgene | PC | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin | 18456258 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-XV-A9W5-01A | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| TCGA | LD | SKCM | TCGA-XV-A9W5-01A | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000334126 | ENST00000393958 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| Frame-shift | ENST00000334126 | ENST00000393960 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| Frame-shift | ENST00000334126 | ENST00000355677 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| 5CDS-5UTR | ENST00000334126 | ENST00000524491 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000334126 | ENST00000529047 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000334126 | ENST00000393955 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000334126 | ENST00000528224 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| Frame-shift | ENST00000313663 | ENST00000393958 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| Frame-shift | ENST00000313663 | ENST00000393960 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| Frame-shift | ENST00000313663 | ENST00000355677 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| 5CDS-5UTR | ENST00000313663 | ENST00000524491 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000313663 | ENST00000529047 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000313663 | ENST00000393955 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000313663 | ENST00000528224 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| intron-3CDS | ENST00000542452 | ENST00000393958 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| intron-3CDS | ENST00000542452 | ENST00000393960 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| intron-3CDS | ENST00000542452 | ENST00000355677 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| intron-5UTR | ENST00000542452 | ENST00000524491 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| intron-intron | ENST00000542452 | ENST00000529047 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| intron-intron | ENST00000542452 | ENST00000393955 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| intron-intron | ENST00000542452 | ENST00000528224 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| Frame-shift | ENST00000539061 | ENST00000393958 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| Frame-shift | ENST00000539061 | ENST00000393960 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| Frame-shift | ENST00000539061 | ENST00000355677 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| 5CDS-5UTR | ENST00000539061 | ENST00000524491 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000539061 | ENST00000529047 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000539061 | ENST00000393955 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000539061 | ENST00000528224 | C2CD3 | chr11 | 73879389 | - | PC | chr11 | 66639630 | - |
| In-frame | ENST00000334126 | ENST00000393958 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| In-frame | ENST00000334126 | ENST00000393960 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| In-frame | ENST00000334126 | ENST00000355677 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| 5CDS-5UTR | ENST00000334126 | ENST00000524491 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000334126 | ENST00000529047 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000334126 | ENST00000393955 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000334126 | ENST00000528224 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| In-frame | ENST00000313663 | ENST00000393958 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| In-frame | ENST00000313663 | ENST00000393960 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| In-frame | ENST00000313663 | ENST00000355677 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| 5CDS-5UTR | ENST00000313663 | ENST00000524491 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000313663 | ENST00000529047 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000313663 | ENST00000393955 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000313663 | ENST00000528224 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| intron-3CDS | ENST00000542452 | ENST00000393958 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| intron-3CDS | ENST00000542452 | ENST00000393960 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| intron-3CDS | ENST00000542452 | ENST00000355677 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| intron-5UTR | ENST00000542452 | ENST00000524491 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| intron-intron | ENST00000542452 | ENST00000529047 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| intron-intron | ENST00000542452 | ENST00000393955 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| intron-intron | ENST00000542452 | ENST00000528224 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| In-frame | ENST00000539061 | ENST00000393958 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| In-frame | ENST00000539061 | ENST00000393960 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| In-frame | ENST00000539061 | ENST00000355677 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| 5CDS-5UTR | ENST00000539061 | ENST00000524491 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000539061 | ENST00000529047 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000539061 | ENST00000393955 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
| 5CDS-intron | ENST00000539061 | ENST00000528224 | C2CD3 | chr11 | 73872444 | - | PC | chr11 | 66639630 | - |
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FusionProtFeatures for C2CD3_PC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C2CD3 | PC |