|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 4928 |
FusionGeneSummary for C2CD3_COA4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C2CD3_COA4 | Fusion gene ID: 4928 | Hgene | Tgene | Gene symbol | C2CD3 | COA4 | Gene ID | 26005 | 51287 |
| Gene name | C2 calcium dependent domain containing 3 | cytochrome c oxidase assembly factor 4 homolog | |
| Synonyms | OFD14 | CHCHD8|CMC3|E2IG2 | |
| Cytomap | 11q13.4 | 11q13.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | C2 domain-containing protein 3 | cytochrome c oxidase assembly factor 4 homolog, mitochondrialE2-induced gene 2 proteincoiled-coil-helix-coiled-coil-helix domain containing 8coiled-coil-helix-coiled-coil-helix domain-containing protein 8 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q4AC94 | Q9NYJ1 | |
| Ensembl transtripts involved in fusion gene | ENST00000334126, ENST00000313663, ENST00000542452, ENST00000539061, | ENST00000355693, ENST00000545127, ENST00000541455, ENST00000537289, ENST00000537581, | |
| Fusion gene scores | * DoF score | 13 X 11 X 8=1144 | 5 X 2 X 4=40 |
| # samples | 14 | 5 | |
| ** MAII score | log2(14/1144*10)=-3.03058831983342 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: C2CD3 [Title/Abstract] AND COA4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | C2CD3 | GO:0061511 | centriole elongation | 24997988 |
| Hgene | C2CD3 | GO:0071539 | protein localization to centrosome | 24997988 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-64-1679-01A | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000334126 | ENST00000355693 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| 5CDS-5UTR | ENST00000334126 | ENST00000545127 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| 5CDS-5UTR | ENST00000334126 | ENST00000541455 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| 5CDS-5UTR | ENST00000334126 | ENST00000537289 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| 5CDS-intron | ENST00000334126 | ENST00000537581 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| 5CDS-5UTR | ENST00000313663 | ENST00000355693 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| 5CDS-5UTR | ENST00000313663 | ENST00000545127 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| 5CDS-5UTR | ENST00000313663 | ENST00000541455 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| 5CDS-5UTR | ENST00000313663 | ENST00000537289 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| 5CDS-intron | ENST00000313663 | ENST00000537581 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| intron-5UTR | ENST00000542452 | ENST00000355693 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| intron-5UTR | ENST00000542452 | ENST00000545127 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| intron-5UTR | ENST00000542452 | ENST00000541455 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| intron-5UTR | ENST00000542452 | ENST00000537289 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| intron-intron | ENST00000542452 | ENST00000537581 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| intron-5UTR | ENST00000539061 | ENST00000355693 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| intron-5UTR | ENST00000539061 | ENST00000545127 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| intron-5UTR | ENST00000539061 | ENST00000541455 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| intron-5UTR | ENST00000539061 | ENST00000537289 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
| intron-intron | ENST00000539061 | ENST00000537581 | C2CD3 | chr11 | 73801858 | - | COA4 | chr11 | 73584439 | - |
Top |
FusionProtFeatures for C2CD3_COA4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C2CD3 | COA4 |