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Fusion gene ID: 4925 |
FusionGeneSummary for C2CD2_SH3BGRL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C2CD2_SH3BGRL | Fusion gene ID: 4925 | Hgene | Tgene | Gene symbol | C2CD2 | SH3BGRL | Gene ID | 25966 | 6451 |
| Gene name | C2 calcium dependent domain containing 2 | SH3 domain binding glutamate rich protein like | |
| Synonyms | C21orf25|C21orf258|TMEM24L | HEL-S-115|SH3BGR | |
| Cytomap | 21q22.3 | Xq21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | C2 domain-containing protein 2TMEM24 related gemetransmembrane protein 24-like | SH3 domain-binding glutamic acid-rich-like proteinSH3 domain binding glutamic acid-rich protein likeSH3-binding domain glutamic acid-rich protein likeepididymis secretory protein Li 115 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9Y426 | O75368 | |
| Ensembl transtripts involved in fusion gene | ENST00000329623, ENST00000380486, ENST00000478372, | ENST00000373212, ENST00000481106, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 3 X 2 X 3=18 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: C2CD2 [Title/Abstract] AND SH3BGRL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCS | TCGA-ND-A4W6-01A | C2CD2 | chr21 | 43362256 | - | SH3BGRL | chrX | 80532483 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000329623 | ENST00000373212 | C2CD2 | chr21 | 43362256 | - | SH3BGRL | chrX | 80532483 | + |
| intron-3UTR | ENST00000329623 | ENST00000481106 | C2CD2 | chr21 | 43362256 | - | SH3BGRL | chrX | 80532483 | + |
| In-frame | ENST00000380486 | ENST00000373212 | C2CD2 | chr21 | 43362256 | - | SH3BGRL | chrX | 80532483 | + |
| 5CDS-3UTR | ENST00000380486 | ENST00000481106 | C2CD2 | chr21 | 43362256 | - | SH3BGRL | chrX | 80532483 | + |
| intron-3CDS | ENST00000478372 | ENST00000373212 | C2CD2 | chr21 | 43362256 | - | SH3BGRL | chrX | 80532483 | + |
| intron-3UTR | ENST00000478372 | ENST00000481106 | C2CD2 | chr21 | 43362256 | - | SH3BGRL | chrX | 80532483 | + |
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FusionProtFeatures for C2CD2_SH3BGRL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C2CD2 | SH3BGRL |