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Fusion gene ID: 4789 |
FusionGeneSummary for C19orf25_KLF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C19orf25_KLF2 | Fusion gene ID: 4789 | Hgene | Tgene | Gene symbol | C19orf25 | KLF2 | Gene ID | 148223 | 10365 |
| Gene name | chromosome 19 open reading frame 25 | Kruppel like factor 2 | |
| Synonyms | - | LKLF | |
| Cytomap | 19p13.3 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | UPF0449 protein C19orf25 | Krueppel-like factor 2Kruppel-like factor 2 (lung)Kruppel-like factor LKLFlung Kruppel-like factorlung Kruppel-like zinc finger transcription factorlung krueppel-like factor | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9UFG5 | Q9Y5W3 | |
| Ensembl transtripts involved in fusion gene | ENST00000588427, ENST00000436106, ENST00000588871, ENST00000427685, ENST00000588849, ENST00000586564, ENST00000592872, ENST00000585675, ENST00000591027, | ENST00000248071, ENST00000592003, | |
| Fusion gene scores | * DoF score | 5 X 2 X 5=50 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/50*10)=0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: C19orf25 [Title/Abstract] AND KLF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KLF2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 26299712 |
| Tgene | KLF2 | GO:0045429 | positive regulation of nitric oxide biosynthetic process | 21768538 |
| Tgene | KLF2 | GO:0045893 | positive regulation of transcription, DNA-templated | 21063504 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AJ713185 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000588427 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000588427 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000436106 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000436106 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000588871 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000588871 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| intron-3CDS | ENST00000427685 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| intron-3CDS | ENST00000427685 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| In-frame | ENST00000588849 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| In-frame | ENST00000588849 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| In-frame | ENST00000586564 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| In-frame | ENST00000586564 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| In-frame | ENST00000592872 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| In-frame | ENST00000592872 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000585675 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| Frame-shift | ENST00000585675 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| 5UTR-3CDS | ENST00000591027 | ENST00000248071 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
| 5UTR-3CDS | ENST00000591027 | ENST00000592003 | C19orf25 | chr19 | 1478771 | - | KLF2 | chr19 | 16437665 | + |
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FusionProtFeatures for C19orf25_KLF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C19orf25 | KLF2 |