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Fusion gene ID: 4779 |
FusionGeneSummary for C18orf25_NDRG1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C18orf25_NDRG1 | Fusion gene ID: 4779 | Hgene | Tgene | Gene symbol | C18orf25 | NDRG1 | Gene ID | 147339 | 10397 |
| Gene name | chromosome 18 open reading frame 25 | N-myc downstream regulated 1 | |
| Synonyms | ARKL1|Ark2N|RNF111L1 | CAP43|CMT4D|DRG-1|DRG1|GC4|HMSNL|NDR1|NMSL|PROXY1|RIT42|RTP|TARG1|TDD5 | |
| Cytomap | 18q21.1 | 8q24.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | uncharacterized protein C18orf25ARKadia-like 1ARKadia-like protein 1 | protein NDRG1N-myc downstream-regulated gene 1 proteindifferentiation-related gene 1 proteinnickel-specific induction protein Cap43protein regulated by oxygen-1reducing agents and tunicamycin-responsive protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q96B23 | Q92597 | |
| Ensembl transtripts involved in fusion gene | ENST00000282059, ENST00000321319, | ENST00000323851, ENST00000354944, ENST00000521414, ENST00000537882, ENST00000414097, ENST00000518176, ENST00000522476, ENST00000518066, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 8 X 9 X 2=144 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/144*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: C18orf25 [Title/Abstract] AND NDRG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF748553 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000282059 | ENST00000323851 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000282059 | ENST00000354944 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000282059 | ENST00000521414 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000282059 | ENST00000537882 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000282059 | ENST00000414097 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000282059 | ENST00000518176 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000282059 | ENST00000522476 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000282059 | ENST00000518066 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000321319 | ENST00000323851 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000321319 | ENST00000354944 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000321319 | ENST00000521414 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000321319 | ENST00000537882 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000321319 | ENST00000414097 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000321319 | ENST00000518176 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000321319 | ENST00000522476 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
| 3UTR-intron | ENST00000321319 | ENST00000518066 | C18orf25 | chr18 | 43845243 | + | NDRG1 | chr8 | 134299997 | - |
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FusionProtFeatures for C18orf25_NDRG1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C18orf25 | NDRG1 |