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Fusion gene ID: 473 |
FusionGeneSummary for ACSF2_ANAPC16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACSF2_ANAPC16 | Fusion gene ID: 473 | Hgene | Tgene | Gene symbol | ACSF2 | ANAPC16 | Gene ID | 80221 | 119504 |
| Gene name | acyl-CoA synthetase family member 2 | anaphase promoting complex subunit 16 | |
| Synonyms | ACSMW|AVYV493 | APC16|C10orf104|CENP-27|MSAG|bA570G20.3 | |
| Cytomap | 17q21.33 | 10q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | acyl-CoA synthetase family member 2, mitochondrialPPARG binding, long chain fatty acid acyl Co-A ligase like | anaphase-promoting complex subunit 16centromere protein 27cyclosome subunit 16metabolic syndrome-associated protein | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q96CM8 | Q96DE5 | |
| Ensembl transtripts involved in fusion gene | ENST00000541920, ENST00000300441, ENST00000504392, ENST00000427954, ENST00000502667, ENST00000506085, | ENST00000299381, ENST00000470481, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 8 X 7 X 5=280 |
| # samples | 4 | 11 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/280*10)=-1.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACSF2 [Title/Abstract] AND ANAPC16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ANAPC16 | GO:0016567 | protein ubiquitination | 20360068 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ183620 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000541920 | ENST00000299381 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
| intron-intron | ENST00000541920 | ENST00000470481 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
| intron-intron | ENST00000300441 | ENST00000299381 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
| intron-intron | ENST00000300441 | ENST00000470481 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
| intron-intron | ENST00000504392 | ENST00000299381 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
| intron-intron | ENST00000504392 | ENST00000470481 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
| intron-intron | ENST00000427954 | ENST00000299381 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
| intron-intron | ENST00000427954 | ENST00000470481 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
| intron-intron | ENST00000502667 | ENST00000299381 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
| intron-intron | ENST00000502667 | ENST00000470481 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
| intron-intron | ENST00000506085 | ENST00000299381 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
| intron-intron | ENST00000506085 | ENST00000470481 | ACSF2 | chr17 | 48542799 | + | ANAPC16 | chr10 | 73770944 | - |
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FusionProtFeatures for ACSF2_ANAPC16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACSF2 | ANAPC16 |