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Fusion gene ID: 4688 |
FusionGeneSummary for C12orf66_NXF3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C12orf66_NXF3 | Fusion gene ID: 4688 | Hgene | Tgene | Gene symbol | C12orf66 | NXF3 | Gene ID | 144577 | 56000 |
| Gene name | chromosome 12 open reading frame 66 | nuclear RNA export factor 3 | |
| Synonyms | - | - | |
| Cytomap | 12q14.2 | Xq22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | KICSTOR complex protein C12orf66UPF0536 protein C12orf66 | nuclear RNA export factor 3TAP-like protein 3TAPL-3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96MD2 | Q9H4D5 | |
| Ensembl transtripts involved in fusion gene | ENST00000311915, ENST00000544871, ENST00000398055, ENST00000540673, | ENST00000395065, ENST00000425644, ENST00000425463, | |
| Fusion gene scores | * DoF score | 4 X 2 X 2=16 | 4 X 2 X 2=16 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: C12orf66 [Title/Abstract] AND NXF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NXF3 | GO:0006406 | mRNA export from nucleus | 11545741 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-HB-A3YV-01A | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000311915 | ENST00000395065 | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
| 5CDS-5UTR | ENST00000311915 | ENST00000425644 | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
| 5CDS-intron | ENST00000311915 | ENST00000425463 | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
| Frame-shift | ENST00000544871 | ENST00000395065 | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
| 5CDS-5UTR | ENST00000544871 | ENST00000425644 | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
| 5CDS-intron | ENST00000544871 | ENST00000425463 | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
| Frame-shift | ENST00000398055 | ENST00000395065 | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
| 5CDS-5UTR | ENST00000398055 | ENST00000425644 | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
| 5CDS-intron | ENST00000398055 | ENST00000425463 | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
| intron-3CDS | ENST00000540673 | ENST00000395065 | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
| intron-5UTR | ENST00000540673 | ENST00000425644 | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
| intron-intron | ENST00000540673 | ENST00000425463 | C12orf66 | chr12 | 64609458 | - | NXF3 | chrX | 102339811 | - |
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FusionProtFeatures for C12orf66_NXF3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| C12orf66 | NXF3 |