|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 4559 |
FusionGeneSummary for BTG2_BTG2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BTG2_BTG2 | Fusion gene ID: 4559 | Hgene | Tgene | Gene symbol | BTG2 | BTG2 | Gene ID | 7832 | 7832 |
| Gene name | BTG anti-proliferation factor 2 | BTG anti-proliferation factor 2 | |
| Synonyms | APRO1|PC3|TIS21 | APRO1|PC3|TIS21 | |
| Cytomap | 1q32.1 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein BTG2B-cell translocation gene 2BTG family member 2NGF-inducible anti-proliferative protein PC3nerve growth factor-inducible anti-proliferativepheochromacytoma cell-3 | protein BTG2B-cell translocation gene 2BTG family member 2NGF-inducible anti-proliferative protein PC3nerve growth factor-inducible anti-proliferativepheochromacytoma cell-3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P78543 | P78543 | |
| Ensembl transtripts involved in fusion gene | ENST00000290551, | ENST00000290551, | |
| Fusion gene scores | * DoF score | 1 X 3 X 1=3 | 3 X 5 X 1=15 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/3*10)=3.73696559416621 | log2(6/15*10)=2 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BTG2 [Title/Abstract] AND BTG2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BTG2 | GO:0006974 | cellular response to DNA damage stimulus | 8944033 |
| Hgene | BTG2 | GO:0017148 | negative regulation of translation | 23236473 |
| Hgene | BTG2 | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 18337750 |
| Tgene | BTG2 | GO:0006974 | cellular response to DNA damage stimulus | 8944033 |
| Tgene | BTG2 | GO:0017148 | negative regulation of translation | 23236473 |
| Tgene | BTG2 | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 18337750 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW794369 | BTG2 | chr1 | 203278163 | - | BTG2 | chr1 | 203277952 | + | ||
| ChiTaRS3.1 | CD240342 | BTG2 | chr1 | 203278712 | + | BTG2 | chr1 | 203278580 | - | ||
| ChiTaRS3.1 | CD240348 | BTG2 | chr1 | 203278712 | + | BTG2 | chr1 | 203278580 | - | ||
| ChiTaRS3.1 | BE935216 | BTG2 | chr1 | 203277314 | - | BTG2 | chr1 | 203277899 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000290551 | ENST00000290551 | BTG2 | chr1 | 203278163 | - | BTG2 | chr1 | 203277952 | + |
| 3UTR-3UTR | ENST00000290551 | ENST00000290551 | BTG2 | chr1 | 203278712 | + | BTG2 | chr1 | 203278580 | - |
| 3UTR-3UTR | ENST00000290551 | ENST00000290551 | BTG2 | chr1 | 203277314 | - | BTG2 | chr1 | 203277899 | - |
Top |
FusionProtFeatures for BTG2_BTG2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BTG2 | BTG2 |