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Fusion gene ID: 4557

FusionGeneSummary for BTF3_STAU1

Fusion gene summary

Fusion gene information	Fusion gene name: BTF3_STAU1
	Fusion gene ID: 4557
		Hgene	Tgene
	Gene symbol	BTF3	STAU1
	Gene ID	10384	6780
	Gene name	butyrophilin subfamily 3 member A3	staufen double-stranded RNA binding protein 1
	Synonyms	BTF3\|BTN3.3	PPP1R150\|STAU
	Cytomap	6p22.2	20q13.13
	Type of gene	protein-coding	protein-coding
	Description	butyrophilin subfamily 3 member A3butyrophilin 3butyrophilin subfamily 3 member A3 secreted isoform	double-stranded RNA-binding protein Staufen homolog 1protein phosphatase 1, regulatory subunit 150staufen, RNA binding protein, homolog 1
	Modification date	20180523	20180522
	UniProtAcc	P20290	O95793
	Ensembl transtripts involved in fusion gene	ENST00000335895, ENST00000514505, ENST00000380591,	ENST00000371828, ENST00000371802, ENST00000371856, ENST00000347458, ENST00000340954, ENST00000371792, ENST00000360426,
Fusion gene scores	* DoF score	2 X 2 X 1=4	4 X 5 X 3=60
	# samples	4	5
	** MAII score	log2(4/4*10)=3.32192809488736	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BTF3 [Title/Abstract] AND STAU1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA025528	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000335895	ENST00000371828	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000335895	ENST00000371802	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000335895	ENST00000371856	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000335895	ENST00000347458	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000335895	ENST00000340954	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000335895	ENST00000371792	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000335895	ENST00000360426	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
Frame-shift	ENST00000514505	ENST00000371828	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
Frame-shift	ENST00000514505	ENST00000371802	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
Frame-shift	ENST00000514505	ENST00000371856	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
Frame-shift	ENST00000514505	ENST00000347458	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
Frame-shift	ENST00000514505	ENST00000340954	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
Frame-shift	ENST00000514505	ENST00000371792	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
Frame-shift	ENST00000514505	ENST00000360426	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000380591	ENST00000371828	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000380591	ENST00000371802	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000380591	ENST00000371856	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000380591	ENST00000347458	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000380591	ENST00000340954	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000380591	ENST00000371792	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+
3UTR-3CDS	ENST00000380591	ENST00000360426	BTF3	chr5	72801260	-	STAU1	chr20	47739698	+

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FusionProtFeatures for BTF3_STAU1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BTF3 P20290	STAU1 O95793

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Fusion gene ID: 4557

FusionGeneSummary for BTF3_STAU1

FusionProtFeatures for BTF3_STAU1