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Fusion gene ID: 454 |
FusionGeneSummary for ACP6_PRIM2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACP6_PRIM2 | Fusion gene ID: 454 | Hgene | Tgene | Gene symbol | ACP6 | PRIM2 | Gene ID | 51205 | 5558 |
| Gene name | acid phosphatase 6, lysophosphatidic | DNA primase subunit 2 | |
| Synonyms | ACPL1|LPAP|PACPL1 | PRIM2A|p58 | |
| Cytomap | 1q21.2 | 6p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysophosphatidic acid phosphatase type 6acid phosphatase-like protein 1 | DNA primase large subunitDNA primase 58 kDa subunitprimase (DNA) subunit 2primase, DNA, polypeptide 2 (58kDa) | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NPH0 | ||
| Ensembl transtripts involved in fusion gene | ENST00000369238, ENST00000460583, ENST00000392988, | ENST00000607273, ENST00000389488, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ACP6 [Title/Abstract] AND PRIM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACP6 | GO:2001311 | lysobisphosphatidic acid metabolic process | 23807634 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ345327 | ACP6 | chr1 | 147119192 | - | PRIM2 | chr6 | 57343364 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000369238 | ENST00000607273 | ACP6 | chr1 | 147119192 | - | PRIM2 | chr6 | 57343364 | - |
| intron-intron | ENST00000369238 | ENST00000389488 | ACP6 | chr1 | 147119192 | - | PRIM2 | chr6 | 57343364 | - |
| intron-intron | ENST00000460583 | ENST00000607273 | ACP6 | chr1 | 147119192 | - | PRIM2 | chr6 | 57343364 | - |
| intron-intron | ENST00000460583 | ENST00000389488 | ACP6 | chr1 | 147119192 | - | PRIM2 | chr6 | 57343364 | - |
| intron-intron | ENST00000392988 | ENST00000607273 | ACP6 | chr1 | 147119192 | - | PRIM2 | chr6 | 57343364 | - |
| intron-intron | ENST00000392988 | ENST00000389488 | ACP6 | chr1 | 147119192 | - | PRIM2 | chr6 | 57343364 | - |
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FusionProtFeatures for ACP6_PRIM2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACP6 | PRIM2 |