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Fusion gene ID: 4463 |
FusionGeneSummary for BRWD1_ABCA10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BRWD1_ABCA10 | Fusion gene ID: 4463 | Hgene | Tgene | Gene symbol | BRWD1 | ABCA10 | Gene ID | 54014 | 10349 |
| Gene name | bromodomain and WD repeat domain containing 1 | ATP binding cassette subfamily A member 10 | |
| Synonyms | C21orf107|DCAF19|N143|WDR9|WRD9 | EST698739 | |
| Cytomap | 21q22.2 | 17q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143 | ATP-binding cassette sub-family A member 10ATP-binding cassette A10ATP-binding cassette, sub-family A (ABC1), member 10 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NSI6 | Q8WWZ4 | |
| Ensembl transtripts involved in fusion gene | ENST00000333229, ENST00000342449, ENST00000380800, ENST00000341322, ENST00000470108, | ENST00000416101, ENST00000269081, ENST00000432313, ENST00000519732, ENST00000423818, | |
| Fusion gene scores | * DoF score | 14 X 13 X 8=1456 | 3 X 3 X 3=27 |
| # samples | 15 | 3 | |
| ** MAII score | log2(15/1456*10)=-3.27897594970282 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BRWD1 [Title/Abstract] AND ABCA10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AC-A6IW-01A | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000333229 | ENST00000416101 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-3UTR | ENST00000333229 | ENST00000269081 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-intron | ENST00000333229 | ENST00000432313 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-intron | ENST00000333229 | ENST00000519732 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-intron | ENST00000333229 | ENST00000423818 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-3UTR | ENST00000342449 | ENST00000416101 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-3UTR | ENST00000342449 | ENST00000269081 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-intron | ENST00000342449 | ENST00000432313 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-intron | ENST00000342449 | ENST00000519732 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-intron | ENST00000342449 | ENST00000423818 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-3UTR | ENST00000380800 | ENST00000416101 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-3UTR | ENST00000380800 | ENST00000269081 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-intron | ENST00000380800 | ENST00000432313 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-intron | ENST00000380800 | ENST00000519732 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| 5CDS-intron | ENST00000380800 | ENST00000423818 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| intron-3UTR | ENST00000341322 | ENST00000416101 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| intron-3UTR | ENST00000341322 | ENST00000269081 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| intron-intron | ENST00000341322 | ENST00000432313 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| intron-intron | ENST00000341322 | ENST00000519732 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| intron-intron | ENST00000341322 | ENST00000423818 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| intron-3UTR | ENST00000470108 | ENST00000416101 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| intron-3UTR | ENST00000470108 | ENST00000269081 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| intron-intron | ENST00000470108 | ENST00000432313 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| intron-intron | ENST00000470108 | ENST00000519732 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
| intron-intron | ENST00000470108 | ENST00000423818 | BRWD1 | chr21 | 40619627 | - | ABCA10 | chr17 | 67184020 | - |
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FusionProtFeatures for BRWD1_ABCA10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BRWD1 | ABCA10 |