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Fusion gene ID: 444 |
FusionGeneSummary for ACOXL_SSB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACOXL_SSB | Fusion gene ID: 444 | Hgene | Tgene | Gene symbol | ACOXL | SSB | Gene ID | 55289 | 6741 |
| Gene name | acyl-CoA oxidase like | Sjogren syndrome antigen B | |
| Synonyms | - | LARP3|La|La/SSB | |
| Cytomap | 2q13 | 2q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | acyl-coenzyme A oxidase-like proteinacyl-CoA oxidase-like protein | lupus La proteinLa ribonucleoprotein domain family, member 3SS-BSS-B/La proteinautoantigen Lala autoantigenlupus La antigensjoegren syndrome type B antigen | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9NUZ1 | P05455 | |
| Ensembl transtripts involved in fusion gene | ENST00000389811, ENST00000439055, ENST00000340561, ENST00000496981, | ENST00000260956, ENST00000409333, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 4 X 5=80 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/32*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACOXL [Title/Abstract] AND SSB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SSB | GO:0075522 | IRES-dependent viral translational initiation | 12384597 |
| Tgene | SSB | GO:1903608 | protein localization to cytoplasmic stress granule | 24965446 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-G2-AA3F-01A | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000389811 | ENST00000260956 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
| 5UTR-5UTR | ENST00000389811 | ENST00000409333 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
| 5UTR-5UTR | ENST00000439055 | ENST00000260956 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
| 5UTR-5UTR | ENST00000439055 | ENST00000409333 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
| 5UTR-5UTR | ENST00000340561 | ENST00000260956 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
| 5UTR-5UTR | ENST00000340561 | ENST00000409333 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
| intron-5UTR | ENST00000496981 | ENST00000260956 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
| intron-5UTR | ENST00000496981 | ENST00000409333 | ACOXL | chr2 | 111490351 | + | SSB | chr2 | 170657462 | + |
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FusionProtFeatures for ACOXL_SSB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACOXL | SSB |