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Fusion gene ID: 4422

FusionGeneSummary for BRD9_STARD3

Fusion gene summary

Fusion gene information	Fusion gene name: BRD9_STARD3
	Fusion gene ID: 4422
		Hgene	Tgene
	Gene symbol	BRD9	STARD3
	Gene ID	65980	10948
	Gene name	bromodomain containing 9	StAR related lipid transfer domain containing 3
	Synonyms	LAVS3040\|PRO9856	CAB1\|MLN64\|es64
	Cytomap	5p15.33	17q12
	Type of gene	protein-coding	protein-coding
	Description	bromodomain-containing protein 9rhabdomyosarcoma antigen MU-RMS-40.8sarcoma antigen NY-SAR-29	stAR-related lipid transfer protein 3MLN 64START domain-containing protein 3StAR-related lipid transfer (START) domain containing 3metastatic lymph node gene 64 proteinmetastatic lymph node protein 64steroidogenic acute regulatory protein related
	Modification date	20180519	20180522
	UniProtAcc	Q9H8M2	Q14849
	Ensembl transtripts involved in fusion gene	ENST00000388890, ENST00000323510, ENST00000483173, ENST00000467963, ENST00000435709, ENST00000494422,	ENST00000336308, ENST00000578232, ENST00000544210, ENST00000394250, ENST00000580611,
Fusion gene scores	* DoF score	8 X 9 X 6=432	10 X 3 X 7=210
	# samples	10	10
	** MAII score	log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BRD9 [Title/Abstract] AND STARD3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	STARD3	GO:0030301	cholesterol transport	28377464
Tgene	STARD3	GO:0099044	vesicle tethering to endoplasmic reticulum	24105263\|28377464

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	ESCA	TCGA-R6-A8W5-01B	BRD9	chr5	876216	-	STARD3	chr17	37813261	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000388890	ENST00000336308	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-3UTR	ENST00000388890	ENST00000578232	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-3UTR	ENST00000388890	ENST00000544210	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-3UTR	ENST00000388890	ENST00000394250	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-intron	ENST00000388890	ENST00000580611	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
In-frame	ENST00000323510	ENST00000336308	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-3UTR	ENST00000323510	ENST00000578232	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-3UTR	ENST00000323510	ENST00000544210	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-3UTR	ENST00000323510	ENST00000394250	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-intron	ENST00000323510	ENST00000580611	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
In-frame	ENST00000483173	ENST00000336308	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-3UTR	ENST00000483173	ENST00000578232	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-3UTR	ENST00000483173	ENST00000544210	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-3UTR	ENST00000483173	ENST00000394250	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-intron	ENST00000483173	ENST00000580611	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
In-frame	ENST00000467963	ENST00000336308	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-3UTR	ENST00000467963	ENST00000578232	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-3UTR	ENST00000467963	ENST00000544210	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-3UTR	ENST00000467963	ENST00000394250	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
5CDS-intron	ENST00000467963	ENST00000580611	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
intron-3CDS	ENST00000435709	ENST00000336308	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
intron-3UTR	ENST00000435709	ENST00000578232	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
intron-3UTR	ENST00000435709	ENST00000544210	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
intron-3UTR	ENST00000435709	ENST00000394250	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
intron-intron	ENST00000435709	ENST00000580611	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
intron-3CDS	ENST00000494422	ENST00000336308	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
intron-3UTR	ENST00000494422	ENST00000578232	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
intron-3UTR	ENST00000494422	ENST00000544210	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
intron-3UTR	ENST00000494422	ENST00000394250	BRD9	chr5	876216	-	STARD3	chr17	37813261	+
intron-intron	ENST00000494422	ENST00000580611	BRD9	chr5	876216	-	STARD3	chr17	37813261	+

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FusionProtFeatures for BRD9_STARD3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BRD9 Q9H8M2	STARD3 Q14849

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Fusion gene ID: 4422

FusionGeneSummary for BRD9_STARD3

FusionProtFeatures for BRD9_STARD3