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Fusion gene ID: 4421 |
FusionGeneSummary for BRD9_OSMR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BRD9_OSMR | Fusion gene ID: 4421 | Hgene | Tgene | Gene symbol | BRD9 | OSMR | Gene ID | 65980 | 9180 |
| Gene name | bromodomain containing 9 | oncostatin M receptor | |
| Synonyms | LAVS3040|PRO9856 | IL-31R-beta|IL-31RB|OSMRB|PLCA1 | |
| Cytomap | 5p15.33 | 5p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bromodomain-containing protein 9rhabdomyosarcoma antigen MU-RMS-40.8sarcoma antigen NY-SAR-29 | oncostatin-M-specific receptor subunit betaIL-31 receptor subunit betaIL-31R subunit betainterleukin-31 receptor subunit betaoncostatin-M specific receptor beta subunit | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9H8M2 | Q99650 | |
| Ensembl transtripts involved in fusion gene | ENST00000388890, ENST00000323510, ENST00000483173, ENST00000467963, ENST00000435709, ENST00000494422, | ENST00000274276, ENST00000502536, | |
| Fusion gene scores | * DoF score | 8 X 9 X 6=432 | 3 X 3 X 2=18 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BRD9 [Title/Abstract] AND OSMR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | OSMR | GO:0034097 | response to cytokine | 8999038 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SKCM | TCGA-EB-A42Y-01A | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000388890 | ENST00000274276 | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
| 5CDS-intron | ENST00000388890 | ENST00000502536 | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
| Frame-shift | ENST00000323510 | ENST00000274276 | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
| 5CDS-intron | ENST00000323510 | ENST00000502536 | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
| Frame-shift | ENST00000483173 | ENST00000274276 | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
| 5CDS-intron | ENST00000483173 | ENST00000502536 | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
| Frame-shift | ENST00000467963 | ENST00000274276 | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
| 5CDS-intron | ENST00000467963 | ENST00000502536 | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
| Frame-shift | ENST00000435709 | ENST00000274276 | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
| 5CDS-intron | ENST00000435709 | ENST00000502536 | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
| intron-3CDS | ENST00000494422 | ENST00000274276 | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
| intron-intron | ENST00000494422 | ENST00000502536 | BRD9 | chr5 | 889136 | - | OSMR | chr5 | 38903984 | + |
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FusionProtFeatures for BRD9_OSMR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BRD9 | OSMR |