|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 4412 |
FusionGeneSummary for BRD4_ZC3H15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BRD4_ZC3H15 | Fusion gene ID: 4412 | Hgene | Tgene | Gene symbol | BRD4 | ZC3H15 | Gene ID | 23476 | 55854 |
| Gene name | bromodomain containing 4 | zinc finger CCCH-type containing 15 | |
| Synonyms | CAP|HUNK1|HUNKI|MCAP | HT010|LEREPO4|MSTP012 | |
| Cytomap | 19p13.12 | 2q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bromodomain-containing protein 4chromosome-associated protein | zinc finger CCCH domain-containing protein 15DRG family-regulatory protein 1likely ortholog of mouse immediate early response erythropoietin 4 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | O60885 | Q8WU90 | |
| Ensembl transtripts involved in fusion gene | ENST00000263377, ENST00000371835, ENST00000360016, ENST00000602230, | ENST00000337859, ENST00000544130, ENST00000468120, | |
| Fusion gene scores | * DoF score | 14 X 6 X 10=840 | 2 X 2 X 2=8 |
| # samples | 19 | 2 | |
| ** MAII score | log2(19/840*10)=-2.14438990933517 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: BRD4 [Title/Abstract] AND ZC3H15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BRD4 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 19103749|23086925 |
| Hgene | BRD4 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 19103749 |
| Hgene | BRD4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23086925|23317504 |
| Hgene | BRD4 | GO:0050727 | regulation of inflammatory response | 19103749 |
| Hgene | BRD4 | GO:1901407 | regulation of phosphorylation of RNA polymerase II C-terminal domain | 23086925 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-HU-A4GH-01A | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000263377 | ENST00000337859 | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
| intron-intron | ENST00000263377 | ENST00000544130 | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
| intron-3UTR | ENST00000263377 | ENST00000468120 | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
| intron-3CDS | ENST00000371835 | ENST00000337859 | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
| intron-intron | ENST00000371835 | ENST00000544130 | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
| intron-3UTR | ENST00000371835 | ENST00000468120 | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
| 5UTR-3CDS | ENST00000360016 | ENST00000337859 | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
| 5UTR-intron | ENST00000360016 | ENST00000544130 | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
| 5UTR-3UTR | ENST00000360016 | ENST00000468120 | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
| intron-3CDS | ENST00000602230 | ENST00000337859 | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
| intron-intron | ENST00000602230 | ENST00000544130 | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
| intron-3UTR | ENST00000602230 | ENST00000468120 | BRD4 | chr19 | 15443101 | - | ZC3H15 | chr2 | 187367223 | + |
Top |
FusionProtFeatures for BRD4_ZC3H15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BRD4 | ZC3H15 |