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Fusion gene ID: 4408 |
FusionGeneSummary for BRD4_NUTM1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BRD4_NUTM1 | Fusion gene ID: 4408 | Hgene | Tgene | Gene symbol | BRD4 | NUTM1 | Gene ID | 23476 | 256646 |
| Gene name | bromodomain containing 4 | NUT midline carcinoma family member 1 | |
| Synonyms | CAP|HUNK1|HUNKI|MCAP | C15orf55|FAM22H|NUT | |
| Cytomap | 19p13.12 | 15q14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bromodomain-containing protein 4chromosome-associated protein | NUT family member 1nuclear protein in testis | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | O60885 | Q86Y26 | |
| Ensembl transtripts involved in fusion gene | ENST00000263377, ENST00000371835, ENST00000360016, ENST00000602230, | ENST00000537011, ENST00000438749, ENST00000333756, | |
| Fusion gene scores | * DoF score | 14 X 6 X 10=840 | 1 X 1 X 1=1 |
| # samples | 19 | 1 | |
| ** MAII score | log2(19/840*10)=-2.14438990933517 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: BRD4 [Title/Abstract] AND NUTM1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BRD4 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 19103749|23086925 |
| Hgene | BRD4 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 19103749 |
| Hgene | BRD4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23086925|23317504 |
| Hgene | BRD4 | GO:0050727 | regulation of inflammatory response | 19103749 |
| Hgene | BRD4 | GO:1901407 | regulation of phosphorylation of RNA polymerase II C-terminal domain | 23086925 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AY166680 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000263377 | ENST00000537011 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
| Frame-shift | ENST00000263377 | ENST00000438749 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
| Frame-shift | ENST00000263377 | ENST00000333756 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
| Frame-shift | ENST00000371835 | ENST00000537011 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
| Frame-shift | ENST00000371835 | ENST00000438749 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
| Frame-shift | ENST00000371835 | ENST00000333756 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
| Frame-shift | ENST00000360016 | ENST00000537011 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
| Frame-shift | ENST00000360016 | ENST00000438749 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
| Frame-shift | ENST00000360016 | ENST00000333756 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
| intron-3CDS | ENST00000602230 | ENST00000537011 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
| intron-3CDS | ENST00000602230 | ENST00000438749 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
| intron-3CDS | ENST00000602230 | ENST00000333756 | BRD4 | chr19 | 15364963 | - | NUTM1 | chr15 | 34640165 | + |
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FusionProtFeatures for BRD4_NUTM1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BRD4 | NUTM1 |