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Fusion gene ID: 43894 |
FusionGeneSummary for ZZZ3_RAD51B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZZZ3_RAD51B | Fusion gene ID: 43894 | Hgene | Tgene | Gene symbol | ZZZ3 | RAD51B | Gene ID | 26009 | 5890 |
| Gene name | zinc finger ZZ-type containing 3 | RAD51 paralog B | |
| Synonyms | ATAC1 | R51H2|RAD51L1|REC2 | |
| Cytomap | 1p31.1 | 14q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ZZ-type zinc finger-containing protein 3ATAC component 1 homologzinc finger, ZZ domain containing 3 | DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IYH5 | O15315 | |
| Ensembl transtripts involved in fusion gene | ENST00000370801, ENST00000370798, ENST00000476275, | ENST00000487861, ENST00000471583, ENST00000487270, ENST00000488612, ENST00000390683, ENST00000469165, | |
| Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 25 X 15 X 8=3000 |
| # samples | 6 | 33 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(33/3000*10)=-3.18442457113743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZZZ3 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA420457 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000370801 | ENST00000487861 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000370801 | ENST00000471583 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000370801 | ENST00000487270 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000370801 | ENST00000488612 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000370801 | ENST00000390683 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000370801 | ENST00000469165 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000370798 | ENST00000487861 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000370798 | ENST00000471583 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000370798 | ENST00000487270 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000370798 | ENST00000488612 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000370798 | ENST00000390683 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000370798 | ENST00000469165 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000476275 | ENST00000487861 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000476275 | ENST00000471583 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000476275 | ENST00000487270 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000476275 | ENST00000488612 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000476275 | ENST00000390683 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
| intron-intron | ENST00000476275 | ENST00000469165 | ZZZ3 | chr1 | 78106038 | + | RAD51B | chr14 | 68603002 | - |
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FusionProtFeatures for ZZZ3_RAD51B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZZZ3 | RAD51B |