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Fusion gene ID: 43864 |
FusionGeneSummary for ZSWIM4_MRI1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZSWIM4_MRI1 | Fusion gene ID: 43864 | Hgene | Tgene | Gene symbol | ZSWIM4 | MRI1 | Gene ID | 65249 | 84245 |
| Gene name | zinc finger SWIM-type containing 4 | methylthioribose-1-phosphate isomerase 1 | |
| Synonyms | - | M1Pi|MRDI|MTNA|Ypr118w | |
| Cytomap | 19p13.13-p13.12 | 19p13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger SWIM domain-containing protein 4zinc finger, SWIM domain containing 4 | methylthioribose-1-phosphate isomeraseMTR-1-P isomeraseS-methyl-5-thioribose-1-phosphate isomerase 1mediator of RhoA-dependent invasionmethylthioribose-1-phosphate isomerase homologtranslation initiation factor eIF-2B subunit alpha/beta/delta-like pr | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H7M6 | Q9BV20 | |
| Ensembl transtripts involved in fusion gene | ENST00000254323, ENST00000440752, | ENST00000319545, ENST00000040663, | |
| Fusion gene scores | * DoF score | 10 X 11 X 7=770 | 3 X 2 X 3=18 |
| # samples | 11 | 3 | |
| ** MAII score | log2(11/770*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZSWIM4 [Title/Abstract] AND MRI1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-0190-01A | ZSWIM4 | chr19 | 13906615 | + | MRI1 | chr19 | 13879375 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000254323 | ENST00000319545 | ZSWIM4 | chr19 | 13906615 | + | MRI1 | chr19 | 13879375 | + |
| 5CDS-intron | ENST00000254323 | ENST00000040663 | ZSWIM4 | chr19 | 13906615 | + | MRI1 | chr19 | 13879375 | + |
| intron-intron | ENST00000440752 | ENST00000319545 | ZSWIM4 | chr19 | 13906615 | + | MRI1 | chr19 | 13879375 | + |
| intron-intron | ENST00000440752 | ENST00000040663 | ZSWIM4 | chr19 | 13906615 | + | MRI1 | chr19 | 13879375 | + |
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FusionProtFeatures for ZSWIM4_MRI1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZSWIM4 | MRI1 |