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Fusion gene ID: 43846

FusionGeneSummary for ZSCAN25_CUX1

Fusion gene summary

Fusion gene information	Fusion gene name: ZSCAN25_CUX1
	Fusion gene ID: 43846
		Hgene	Tgene
	Gene symbol	ZSCAN25	CUX1
	Gene ID	221785	1523
	Gene name	zinc finger and SCAN domain containing 25	cut like homeobox 1
	Synonyms	ZNF498	CASP\|CDP\|CDP/Cut\|CDP1\|COY1\|CUTL1\|CUX\|Clox\|Cux/CDP\|GOLIM6\|Nbla10317\|p100\|p110\|p200\|p75
	Cytomap	7q22.1	7q22.1
	Type of gene	protein-coding	protein-coding
	Description	zinc finger and SCAN domain-containing protein 25zinc finger protein 498	protein CASPCCAAT displacement proteincut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317
	Modification date	20180519	20180523
	UniProtAcc	Q6NSZ9	Q13948
	Ensembl transtripts involved in fusion gene	ENST00000394152, ENST00000334715, ENST00000262941, ENST00000466948,	ENST00000437600, ENST00000292538, ENST00000393824, ENST00000547394, ENST00000360264, ENST00000425244, ENST00000292535, ENST00000549414, ENST00000556210, ENST00000550008, ENST00000546411, ENST00000560541,
Fusion gene scores	* DoF score	2 X 2 X 1=4	12 X 13 X 5=780
	# samples	2	14
	** MAII score	log2(2/4*10)=2.32192809488736	log2(14/780*10)=-2.47804729680464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZSCAN25 [Title/Abstract] AND CUX1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BC036852	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000394152	ENST00000437600	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
In-frame	ENST00000394152	ENST00000292538	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
In-frame	ENST00000394152	ENST00000393824	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
In-frame	ENST00000394152	ENST00000547394	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000394152	ENST00000360264	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000394152	ENST00000425244	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000394152	ENST00000292535	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000394152	ENST00000549414	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000394152	ENST00000556210	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000394152	ENST00000550008	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000394152	ENST00000546411	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-3UTR	ENST00000394152	ENST00000560541	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
In-frame	ENST00000334715	ENST00000437600	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
In-frame	ENST00000334715	ENST00000292538	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
In-frame	ENST00000334715	ENST00000393824	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
In-frame	ENST00000334715	ENST00000547394	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000334715	ENST00000360264	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000334715	ENST00000425244	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000334715	ENST00000292535	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000334715	ENST00000549414	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000334715	ENST00000556210	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000334715	ENST00000550008	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-intron	ENST00000334715	ENST00000546411	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
5CDS-3UTR	ENST00000334715	ENST00000560541	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-3CDS	ENST00000262941	ENST00000437600	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-3CDS	ENST00000262941	ENST00000292538	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-3CDS	ENST00000262941	ENST00000393824	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-3CDS	ENST00000262941	ENST00000547394	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000262941	ENST00000360264	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000262941	ENST00000425244	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000262941	ENST00000292535	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000262941	ENST00000549414	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000262941	ENST00000556210	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000262941	ENST00000550008	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000262941	ENST00000546411	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-3UTR	ENST00000262941	ENST00000560541	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-3CDS	ENST00000466948	ENST00000437600	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-3CDS	ENST00000466948	ENST00000292538	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-3CDS	ENST00000466948	ENST00000393824	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-3CDS	ENST00000466948	ENST00000547394	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000466948	ENST00000360264	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000466948	ENST00000425244	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000466948	ENST00000292535	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000466948	ENST00000549414	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000466948	ENST00000556210	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000466948	ENST00000550008	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-intron	ENST00000466948	ENST00000546411	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+
intron-3UTR	ENST00000466948	ENST00000560541	ZSCAN25	chr7	99221804	+	CUX1	chr7	101916634	+

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FusionProtFeatures for ZSCAN25_CUX1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZSCAN25 Q6NSZ9	CUX1 Q13948

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Fusion gene ID: 43846

FusionGeneSummary for ZSCAN25_CUX1

FusionProtFeatures for ZSCAN25_CUX1