|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 4384 |
FusionGeneSummary for BRCC3_CLIC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BRCC3_CLIC2 | Fusion gene ID: 4384 | Hgene | Tgene | Gene symbol | BRCC3 | CLIC2 | Gene ID | 79184 | 1193 |
| Gene name | BRCA1/BRCA2-containing complex subunit 3 | chloride intracellular channel 2 | |
| Synonyms | BRCC36|C6.1A|CXorf53 | CLIC2b|MRXS32|XAP121 | |
| Cytomap | Xq28 | Xq28 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lys-63-specific deubiquitinase BRCC36BRCA1-A complex subunit BRCC36BRCA1/BRCA2-containing complex subunit 36BRISC complex subunit BRCC36 | chloride intracellular channel protein 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P46736 | O15247 | |
| Ensembl transtripts involved in fusion gene | ENST00000340647, ENST00000330045, ENST00000369459, ENST00000369462, ENST00000399042, | ENST00000369449, ENST00000465553, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: BRCC3 [Title/Abstract] AND CLIC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BRCC3 | GO:0010165 | response to X-ray | 14636569 |
| Hgene | BRCC3 | GO:0070536 | protein K63-linked deubiquitination | 17525341|19214193 |
| Hgene | BRCC3 | GO:0070537 | histone H2A K63-linked deubiquitination | 19202061 |
| Tgene | CLIC2 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 15147738|15916532 |
| Tgene | CLIC2 | GO:0051099 | positive regulation of binding | 15916532 |
| Tgene | CLIC2 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 15147738|15916532 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-1487-01A | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000340647 | ENST00000369449 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| 5CDS-5UTR | ENST00000340647 | ENST00000465553 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| In-frame | ENST00000330045 | ENST00000369449 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| 5CDS-5UTR | ENST00000330045 | ENST00000465553 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| In-frame | ENST00000369459 | ENST00000369449 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| 5CDS-5UTR | ENST00000369459 | ENST00000465553 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| In-frame | ENST00000369462 | ENST00000369449 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| 5CDS-5UTR | ENST00000369462 | ENST00000465553 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| In-frame | ENST00000399042 | ENST00000369449 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
| 5CDS-5UTR | ENST00000399042 | ENST00000465553 | BRCC3 | chrX | 154319114 | + | CLIC2 | chrX | 154509357 | - |
Top |
FusionProtFeatures for BRCC3_CLIC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BRCC3 | CLIC2 |