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Fusion gene ID: 43787 |
FusionGeneSummary for ZNF91_NANOS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF91_NANOS3 | Fusion gene ID: 43787 | Hgene | Tgene | Gene symbol | ZNF91 | NANOS3 | Gene ID | 7644 | 342977 |
| Gene name | zinc finger protein 91 | nanos C2HC-type zinc finger 3 | |
| Synonyms | HPF7|HTF10 | NANOS1L|NOS3|ZC2HC12C | |
| Cytomap | 19p12 | 19p13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 91zinc finger protein 91 (HPF7, HTF10)zinc finger protein HPF7zinc finger protein HTF10 | nanos homolog 3 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q05481 | P60323 | |
| Ensembl transtripts involved in fusion gene | ENST00000596528, ENST00000599743, ENST00000300619, ENST00000397082, | ENST00000591727, ENST00000339133, ENST00000397555, | |
| Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 4 X 1 X 4=16 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF91 [Title/Abstract] AND NANOS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZNF91 | GO:0045892 | negative regulation of transcription, DNA-templated | 25274305 |
| Hgene | ZNF91 | GO:0070895 | negative regulation of transposon integration | 25274305 |
| Tgene | NANOS3 | GO:0017148 | negative regulation of translation | 24736845 |
| Tgene | NANOS3 | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 24736845 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-S9-A7IZ-01A | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000596528 | ENST00000591727 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
| intron-3UTR | ENST00000596528 | ENST00000339133 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
| intron-3UTR | ENST00000596528 | ENST00000397555 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
| 5CDS-3UTR | ENST00000599743 | ENST00000591727 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
| 5CDS-3UTR | ENST00000599743 | ENST00000339133 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
| 5CDS-3UTR | ENST00000599743 | ENST00000397555 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
| 5CDS-3UTR | ENST00000300619 | ENST00000591727 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
| 5CDS-3UTR | ENST00000300619 | ENST00000339133 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
| 5CDS-3UTR | ENST00000300619 | ENST00000397555 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
| 5CDS-3UTR | ENST00000397082 | ENST00000591727 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
| 5CDS-3UTR | ENST00000397082 | ENST00000339133 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
| 5CDS-3UTR | ENST00000397082 | ENST00000397555 | ZNF91 | chr19 | 23578127 | - | NANOS3 | chr19 | 13991256 | + |
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FusionProtFeatures for ZNF91_NANOS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF91 | NANOS3 |