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Fusion gene ID: 43783 |
FusionGeneSummary for ZNF8_SSBP4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF8_SSBP4 | Fusion gene ID: 43783 | Hgene | Tgene | Gene symbol | ZNF8 | SSBP4 | Gene ID | 7554 | 170463 |
| Gene name | zinc finger protein 8 | single stranded DNA binding protein 4 | |
| Synonyms | HF.18|Zfp128 | - | |
| Cytomap | 19q13.43 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 8zinc finger protein 272zinc finger protein 8 (clone HF.18)zinc finger protein HF.18 | single-stranded DNA-binding protein 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P17098 | Q9BWG4 | |
| Ensembl transtripts involved in fusion gene | ENST00000196548, ENST00000608843, | ENST00000348495, ENST00000270061, ENST00000598159, ENST00000599699, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 1 X 3=9 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF8 [Title/Abstract] AND SSBP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-22-5478-01A | ZNF8 | chr19 | 58790513 | + | SSBP4 | chr19 | 18538161 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000196548 | ENST00000348495 | ZNF8 | chr19 | 58790513 | + | SSBP4 | chr19 | 18538161 | + |
| Frame-shift | ENST00000196548 | ENST00000270061 | ZNF8 | chr19 | 58790513 | + | SSBP4 | chr19 | 18538161 | + |
| 5CDS-3UTR | ENST00000196548 | ENST00000598159 | ZNF8 | chr19 | 58790513 | + | SSBP4 | chr19 | 18538161 | + |
| 5CDS-intron | ENST00000196548 | ENST00000599699 | ZNF8 | chr19 | 58790513 | + | SSBP4 | chr19 | 18538161 | + |
| Frame-shift | ENST00000608843 | ENST00000348495 | ZNF8 | chr19 | 58790513 | + | SSBP4 | chr19 | 18538161 | + |
| Frame-shift | ENST00000608843 | ENST00000270061 | ZNF8 | chr19 | 58790513 | + | SSBP4 | chr19 | 18538161 | + |
| 5CDS-3UTR | ENST00000608843 | ENST00000598159 | ZNF8 | chr19 | 58790513 | + | SSBP4 | chr19 | 18538161 | + |
| 5CDS-intron | ENST00000608843 | ENST00000599699 | ZNF8 | chr19 | 58790513 | + | SSBP4 | chr19 | 18538161 | + |
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FusionProtFeatures for ZNF8_SSBP4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF8 | SSBP4 |