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Fusion gene ID: 43750

FusionGeneSummary for ZNF814_USF1

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF814_USF1
	Fusion gene ID: 43750
		Hgene	Tgene
	Gene symbol	ZNF814	USF1
	Gene ID	730051	7391
	Gene name	zinc finger protein 814	upstream transcription factor 1
	Synonyms	-	FCHL\|FCHL1\|HYPLIP1\|MLTF\|MLTFI\|UEF\|bHLHb11
	Cytomap	19q13.43	1q23.3
	Type of gene	protein-coding	protein-coding
	Description	putative uncharacterized zinc finger protein 814	upstream stimulatory factor 1class B basic helix-loop-helix protein 11major late transcription factor 1
	Modification date	20180403	20180522
	UniProtAcc	B7Z6K7	P22415
	Ensembl transtripts involved in fusion gene	ENST00000597652, ENST00000596604, ENST00000597342, ENST00000597832, ENST00000595295, ENST00000600634, ENST00000435989, ENST00000597807,	ENST00000368020, ENST00000368021, ENST00000435396, ENST00000368019,
Fusion gene scores	* DoF score	8 X 6 X 4=192	4 X 6 X 2=48
	# samples	8	6
	** MAII score	log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ZNF814 [Title/Abstract] AND USF1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	USF1	GO:0006366	transcription by RNA polymerase II	2249772
Tgene	USF1	GO:0019086	late viral transcription	2249772
Tgene	USF1	GO:0032869	cellular response to insulin stimulus	19303849

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF932409	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000597652	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597652	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597652	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597652	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000596604	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000596604	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000596604	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000596604	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597342	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597342	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597342	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597342	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597832	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597832	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597832	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597832	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000595295	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000595295	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000595295	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000595295	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000600634	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000600634	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000600634	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000600634	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000435989	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000435989	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000435989	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000435989	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597807	ENST00000368020	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597807	ENST00000368021	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597807	ENST00000435396	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+
intron-intron	ENST00000597807	ENST00000368019	ZNF814	chr19	58379610	-	USF1	chr1	161009971	+

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FusionProtFeatures for ZNF814_USF1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZNF814 B7Z6K7	USF1 P22415

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Fusion gene ID: 43750

FusionGeneSummary for ZNF814_USF1

FusionProtFeatures for ZNF814_USF1