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Fusion gene ID: 43673

FusionGeneSummary for ZNF738_MAU2

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF738_MAU2
	Fusion gene ID: 43673
		Hgene	Tgene
	Gene symbol	ZNF738	MAU2
	Gene ID	148203	23383
	Gene name	zinc finger protein 738	MAU2 sister chromatid cohesion factor
	Synonyms	-	KIAA0892\|MAU2L\|SCC4\|mau-2
	Cytomap	19p12	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	protein ZNF738	MAU2 chromatid cohesion factor homologcohesin loading complex subunit SCC4 homologprotein MAU-2sister chromatid cohesion 4
	Modification date	20180522	20180523
	UniProtAcc	Q8NE65	Q9Y6X3
	Ensembl transtripts involved in fusion gene	ENST00000311015, ENST00000380870, ENST00000597810, ENST00000594245,	ENST00000392313, ENST00000262815, ENST00000586189,
Fusion gene scores	* DoF score	2 X 2 X 2=8	6 X 6 X 3=108
	# samples	2	6
	** MAII score	log2(2/8*10)=1.32192809488736	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF738 [Title/Abstract] AND MAU2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MAU2	GO:0071921	cohesin loading	22628566

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-D8-A140-01A	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000311015	ENST00000392313	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+
In-frame	ENST00000311015	ENST00000262815	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+
5CDS-intron	ENST00000311015	ENST00000586189	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+
In-frame	ENST00000380870	ENST00000392313	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+
In-frame	ENST00000380870	ENST00000262815	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+
5CDS-intron	ENST00000380870	ENST00000586189	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+
In-frame	ENST00000597810	ENST00000392313	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+
In-frame	ENST00000597810	ENST00000262815	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+
5CDS-intron	ENST00000597810	ENST00000586189	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+
In-frame	ENST00000594245	ENST00000392313	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+
In-frame	ENST00000594245	ENST00000262815	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+
5CDS-intron	ENST00000594245	ENST00000586189	ZNF738	chr19	21544660	+	MAU2	chr19	19449654	+

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FusionProtFeatures for ZNF738_MAU2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZNF738 Q8NE65	MAU2 Q9Y6X3

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Fusion gene ID: 43673

FusionGeneSummary for ZNF738_MAU2

FusionProtFeatures for ZNF738_MAU2