|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 43671 |
FusionGeneSummary for ZNF736_SLC25A13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF736_SLC25A13 | Fusion gene ID: 43671 | Hgene | Tgene | Gene symbol | ZNF736 | SLC25A13 | Gene ID | 728927 | 10165 |
| Gene name | zinc finger protein 736 | solute carrier family 25 member 13 | |
| Synonyms | - | ARALAR2|CITRIN|CTLN2 | |
| Cytomap | 7q11.21 | 7q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 736KRAB-containing zinc-finger repressor protein | calcium-binding mitochondrial carrier protein Aralar2mitochondrial aspartate glutamate carrier 2solute carrier family 25 (aspartate/glutamate carrier), member 13 | |
| Modification date | 20180403 | 20180523 | |
| UniProtAcc | B4DX44 | Q9UJS0 | |
| Ensembl transtripts involved in fusion gene | ENST00000465343, ENST00000355095, ENST00000423484, | ENST00000265631, ENST00000416240, ENST00000542654, ENST00000494085, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 7 X 6 X 5=210 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZNF736 [Title/Abstract] AND SLC25A13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SLC25A13 | GO:0006754 | ATP biosynthetic process | 12851387 |
| Tgene | SLC25A13 | GO:0015810 | aspartate transmembrane transport | 11566871 |
| Tgene | SLC25A13 | GO:0015813 | L-glutamate transmembrane transport | 11566871 |
| Tgene | SLC25A13 | GO:0043490 | malate-aspartate shuttle | 11566871 |
| Tgene | SLC25A13 | GO:0045333 | cellular respiration | 12851387 |
| Tgene | SLC25A13 | GO:0051592 | response to calcium ion | 11566871 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA535064 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000465343 | ENST00000265631 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
| intron-3CDS | ENST00000465343 | ENST00000416240 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
| intron-3CDS | ENST00000465343 | ENST00000542654 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
| intron-intron | ENST00000465343 | ENST00000494085 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
| Frame-shift | ENST00000355095 | ENST00000265631 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
| Frame-shift | ENST00000355095 | ENST00000416240 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
| Frame-shift | ENST00000355095 | ENST00000542654 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
| 5CDS-intron | ENST00000355095 | ENST00000494085 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
| Frame-shift | ENST00000423484 | ENST00000265631 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
| Frame-shift | ENST00000423484 | ENST00000416240 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
| Frame-shift | ENST00000423484 | ENST00000542654 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
| 5CDS-intron | ENST00000423484 | ENST00000494085 | ZNF736 | chr7 | 63774531 | + | SLC25A13 | chr7 | 95838290 | - |
Top |
FusionProtFeatures for ZNF736_SLC25A13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF736 | SLC25A13 |