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Fusion gene ID: 43664 |
FusionGeneSummary for ZNF721_YAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF721_YAP1 | Fusion gene ID: 43664 | Hgene | Tgene | Gene symbol | ZNF721 | YAP1 | Gene ID | 170960 | 10413 |
| Gene name | zinc finger protein 721 | Yes associated protein 1 | |
| Synonyms | - | COB1|YAP|YAP2|YAP65|YKI | |
| Cytomap | 4p16.3 | 11q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 721 | transcriptional coactivator YAP165 kDa Yes-associated proteinprotein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q8TF20 | P46937 | |
| Ensembl transtripts involved in fusion gene | ENST00000506646, ENST00000507078, ENST00000338977, ENST00000511833, | ENST00000526343, ENST00000282441, ENST00000537274, ENST00000345877, ENST00000531439, ENST00000524575, ENST00000528834, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 13 X 7 X 11=1001 |
| # samples | 5 | 13 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/1001*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZNF721 [Title/Abstract] AND YAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | YAP1 | GO:0006974 | cellular response to DNA damage stimulus | 18280240 |
| Tgene | YAP1 | GO:0008283 | cell proliferation | 17974916 |
| Tgene | YAP1 | GO:0032570 | response to progesterone | 16772533 |
| Tgene | YAP1 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway | 16772533 |
| Tgene | YAP1 | GO:0045893 | positive regulation of transcription, DNA-templated | 20368466 |
| Tgene | YAP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 25796446 |
| Tgene | YAP1 | GO:0050767 | regulation of neurogenesis | 25433207 |
| Tgene | YAP1 | GO:0050847 | progesterone receptor signaling pathway | 16772533 |
| Tgene | YAP1 | GO:0060242 | contact inhibition | 17974916 |
| Tgene | YAP1 | GO:0065003 | protein-containing complex assembly | 20368466 |
| Tgene | YAP1 | GO:0071480 | cellular response to gamma radiation | 18280240 |
| Tgene | YAP1 | GO:0072091 | regulation of stem cell proliferation | 25433207 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-36-1578-01A | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000506646 | ENST00000526343 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000506646 | ENST00000282441 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000506646 | ENST00000537274 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000506646 | ENST00000345877 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000506646 | ENST00000531439 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000506646 | ENST00000524575 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000506646 | ENST00000528834 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000507078 | ENST00000526343 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000507078 | ENST00000282441 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000507078 | ENST00000537274 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000507078 | ENST00000345877 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000507078 | ENST00000531439 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000507078 | ENST00000524575 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| intron-intron | ENST00000507078 | ENST00000528834 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000338977 | ENST00000526343 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000338977 | ENST00000282441 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000338977 | ENST00000537274 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000338977 | ENST00000345877 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000338977 | ENST00000531439 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000338977 | ENST00000524575 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000338977 | ENST00000528834 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000511833 | ENST00000526343 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000511833 | ENST00000282441 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000511833 | ENST00000537274 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000511833 | ENST00000345877 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000511833 | ENST00000531439 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000511833 | ENST00000524575 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
| 5UTR-intron | ENST00000511833 | ENST00000528834 | ZNF721 | chr4 | 492845 | - | YAP1 | chr11 | 102056749 | + |
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FusionProtFeatures for ZNF721_YAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF721 | YAP1 |