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Fusion gene ID: 43624 |
FusionGeneSummary for ZNF703_ARSJ |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF703_ARSJ | Fusion gene ID: 43624 | Hgene | Tgene | Gene symbol | ZNF703 | ARSJ | Gene ID | 80139 | 79642 |
| Gene name | zinc finger protein 703 | arylsulfatase family member J | |
| Synonyms | NLZ1|ZEPPO1|ZNF503L|ZPO1 | ASJ | |
| Cytomap | 8p11.23 | 4q26 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 703zinc finger elbow-related proline domain protein 1 | arylsulfatase J | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9H7S9 | Q5FYB0 | |
| Ensembl transtripts involved in fusion gene | ENST00000331569, | ENST00000315366, ENST00000541197, ENST00000503013, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZNF703 [Title/Abstract] AND ARSJ [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZNF703 | GO:0006355 | regulation of transcription, DNA-templated | 21328542 |
| Hgene | ZNF703 | GO:0008284 | positive regulation of cell proliferation | 21328542 |
| Hgene | ZNF703 | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 21337521 |
| Hgene | ZNF703 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation | 21337521 |
| Hgene | ZNF703 | GO:0051726 | regulation of cell cycle | 21328542 |
| Hgene | ZNF703 | GO:0060644 | mammary gland epithelial cell differentiation | 21337521 |
| Hgene | ZNF703 | GO:0071392 | cellular response to estradiol stimulus | 21328542 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA558581 | ZNF703 | chr8 | 37556259 | + | ARSJ | chr4 | 114900000 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-5UTR | ENST00000331569 | ENST00000315366 | ZNF703 | chr8 | 37556259 | + | ARSJ | chr4 | 114900000 | - |
| 3UTR-5UTR | ENST00000331569 | ENST00000541197 | ZNF703 | chr8 | 37556259 | + | ARSJ | chr4 | 114900000 | - |
| 3UTR-5UTR | ENST00000331569 | ENST00000503013 | ZNF703 | chr8 | 37556259 | + | ARSJ | chr4 | 114900000 | - |
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FusionProtFeatures for ZNF703_ARSJ |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF703 | ARSJ |