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Fusion gene ID: 43615 |
FusionGeneSummary for ZNF699_NR1I2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF699_NR1I2 | Fusion gene ID: 43615 | Hgene | Tgene | Gene symbol | ZNF699 | NR1I2 | Gene ID | 374879 | 8856 |
| Gene name | zinc finger protein 699 | nuclear receptor subfamily 1 group I member 2 | |
| Synonyms | hang | BXR|ONR1|PAR|PAR1|PAR2|PARq|PRR|PXR|SAR|SXR | |
| Cytomap | 19p13.2 | 3q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 699hangover homologhangover, Drosophila, homolog of | nuclear receptor subfamily 1 group I member 2orphan nuclear receptor PAR1orphan nuclear receptor PXRpregnane X nuclear receptor variant 2pregnane X receptorsteroid and xenobiotic receptor | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | Q32M78 | O75469 | |
| Ensembl transtripts involved in fusion gene | ENST00000308650, ENST00000591998, ENST00000588336, | ENST00000466380, ENST00000393716, ENST00000337940, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZNF699 [Title/Abstract] AND NR1I2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NR1I2 | GO:0006805 | xenobiotic metabolic process | 12578355 |
| Tgene | NR1I2 | GO:0042738 | exogenous drug catabolic process | 12578355 |
| Tgene | NR1I2 | GO:0042908 | xenobiotic transport | 12578355 |
| Tgene | NR1I2 | GO:0045892 | negative regulation of transcription, DNA-templated | 11891224 |
| Tgene | NR1I2 | GO:0045893 | positive regulation of transcription, DNA-templated | 12578355 |
| Tgene | NR1I2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11114890 |
| Tgene | NR1I2 | GO:0046618 | drug export | 12578355 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-SI-A71Q-01A | ZNF699 | chr19 | 9407972 | - | NR1I2 | chr3 | 119526076 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000308650 | ENST00000466380 | ZNF699 | chr19 | 9407972 | - | NR1I2 | chr3 | 119526076 | + |
| 5CDS-5UTR | ENST00000308650 | ENST00000393716 | ZNF699 | chr19 | 9407972 | - | NR1I2 | chr3 | 119526076 | + |
| 5CDS-5UTR | ENST00000308650 | ENST00000337940 | ZNF699 | chr19 | 9407972 | - | NR1I2 | chr3 | 119526076 | + |
| 5CDS-5UTR | ENST00000591998 | ENST00000466380 | ZNF699 | chr19 | 9407972 | - | NR1I2 | chr3 | 119526076 | + |
| 5CDS-5UTR | ENST00000591998 | ENST00000393716 | ZNF699 | chr19 | 9407972 | - | NR1I2 | chr3 | 119526076 | + |
| 5CDS-5UTR | ENST00000591998 | ENST00000337940 | ZNF699 | chr19 | 9407972 | - | NR1I2 | chr3 | 119526076 | + |
| intron-5UTR | ENST00000588336 | ENST00000466380 | ZNF699 | chr19 | 9407972 | - | NR1I2 | chr3 | 119526076 | + |
| intron-5UTR | ENST00000588336 | ENST00000393716 | ZNF699 | chr19 | 9407972 | - | NR1I2 | chr3 | 119526076 | + |
| intron-5UTR | ENST00000588336 | ENST00000337940 | ZNF699 | chr19 | 9407972 | - | NR1I2 | chr3 | 119526076 | + |
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FusionProtFeatures for ZNF699_NR1I2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF699 | NR1I2 |