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Fusion gene ID: 43606 |
FusionGeneSummary for ZNF689_ZNF48 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF689_ZNF48 | Fusion gene ID: 43606 | Hgene | Tgene | Gene symbol | ZNF689 | ZNF48 | Gene ID | 115509 | 197407 |
| Gene name | zinc finger protein 689 | zinc finger protein 48 | |
| Synonyms | TIPUH1 | ZNF553 | |
| Cytomap | 16p11.2 | 16p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 689transcription-involved protein upregulated in HCC 1 | zinc finger protein 48zinc finger protein 553 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q96CS4 | Q96MX3 | |
| Ensembl transtripts involved in fusion gene | ENST00000287461, ENST00000566673, | ENST00000320159, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ZNF689 [Title/Abstract] AND ZNF48 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-0882-01A | ZNF689 | chr16 | 30616402 | - | ZNF48 | chr16 | 30409176 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000287461 | ENST00000320159 | ZNF689 | chr16 | 30616402 | - | ZNF48 | chr16 | 30409176 | + |
| intron-3CDS | ENST00000566673 | ENST00000320159 | ZNF689 | chr16 | 30616402 | - | ZNF48 | chr16 | 30409176 | + |
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FusionProtFeatures for ZNF689_ZNF48 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF689 | ZNF48 |