	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 43594

FusionGeneSummary for ZNF675_SLC27A1

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF675_SLC27A1
	Fusion gene ID: 43594
		Hgene	Tgene
	Gene symbol	ZNF675	SLC27A1
	Gene ID	171392	376497
	Gene name	zinc finger protein 675	solute carrier family 27 member 1
	Synonyms	TBZF\|TIZ	ACSVL5\|FATP\|FATP-1\|FATP1
	Cytomap	19p12	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 675TRAF6 inhibitory zinc fingerTRAF6-binding zinc finger proteinTRAF6-inhibitory zinc finger protein	long-chain fatty acid transport protein 1fatty acid transport protein 1solute carrier family 27 (fatty acid transporter), member 1
	Modification date	20180519	20180522
	UniProtAcc	Q8TD23	Q6PCB7
	Ensembl transtripts involved in fusion gene	ENST00000601935, ENST00000600313, ENST00000596211, ENST00000359788, ENST00000601010, ENST00000599168,	ENST00000442725, ENST00000252595, ENST00000598424, ENST00000598848,
Fusion gene scores	* DoF score	4 X 1 X 4=16	4 X 4 X 4=64
	# samples	4	4
	** MAII score	log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF675 [Title/Abstract] AND SLC27A1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ZNF675	GO:0000122	negative regulation of transcription by RNA polymerase II	11751921
Hgene	ZNF675	GO:0007249	I-kappaB kinase/NF-kappaB signaling	11751921
Hgene	ZNF675	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	11751921
Hgene	ZNF675	GO:0019221	cytokine-mediated signaling pathway	11751921
Hgene	ZNF675	GO:0032088	negative regulation of NF-kappaB transcription factor activity	11751921
Hgene	ZNF675	GO:0043508	negative regulation of JUN kinase activity	11751921
Hgene	ZNF675	GO:0045671	negative regulation of osteoclast differentiation	11751921\|11851921
Hgene	ZNF675	GO:0046329	negative regulation of JNK cascade	11751921
Hgene	ZNF675	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	11751921
Hgene	ZNF675	GO:2000678	negative regulation of transcription regulatory region DNA binding	11751921

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	UCS	TCGA-N8-A4PL-01A	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000601935	ENST00000442725	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000601935	ENST00000252595	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000601935	ENST00000598424	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-intron	ENST00000601935	ENST00000598848	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000600313	ENST00000442725	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000600313	ENST00000252595	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000600313	ENST00000598424	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-intron	ENST00000600313	ENST00000598848	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000596211	ENST00000442725	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000596211	ENST00000252595	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000596211	ENST00000598424	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-intron	ENST00000596211	ENST00000598848	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000359788	ENST00000442725	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000359788	ENST00000252595	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000359788	ENST00000598424	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-intron	ENST00000359788	ENST00000598848	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000601010	ENST00000442725	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000601010	ENST00000252595	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000601010	ENST00000598424	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-intron	ENST00000601010	ENST00000598848	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000599168	ENST00000442725	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000599168	ENST00000252595	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-5UTR	ENST00000599168	ENST00000598424	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+
5CDS-intron	ENST00000599168	ENST00000598848	ZNF675	chr19	23869833	-	SLC27A1	chr19	17581349	+

Top

FusionProtFeatures for ZNF675_SLC27A1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZNF675 Q8TD23	SLC27A1 Q6PCB7

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 43594

FusionGeneSummary for ZNF675_SLC27A1

FusionProtFeatures for ZNF675_SLC27A1