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Fusion gene ID: 43574 |
FusionGeneSummary for ZNF664_AKR1C2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF664_AKR1C2 | Fusion gene ID: 43574 | Hgene | Tgene | Gene symbol | ZNF664 | AKR1C2 | Gene ID | 144348 | 1646 |
| Gene name | zinc finger protein 664 | aldo-keto reductase family 1 member C2 | |
| Synonyms | ZFOC1|ZNF176 | AKR1C-pseudo|BABP|DD|DD-2|DD/BABP|DD2|DDH2|HAKRD|HBAB|MCDR2|SRXY8|TDD | |
| Cytomap | 12q24.31 | 10p15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 664zinc finger Organ of Corti 1zinc finger protein 176zinc finger protein from organ of Corti | aldo-keto reductase family 1 member C23-alpha-HSD3chlordecone reductase homolog HAKRDdihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type IIIpseudo-chlordecone reductasetesticular 17,20-desmolase deficien | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8N3J9 | P52895 | |
| Ensembl transtripts involved in fusion gene | ENST00000537532, ENST00000539644, ENST00000392404, ENST00000538932, ENST00000337815, | ENST00000380753, ENST00000421196, ENST00000407674, ENST00000455190, ENST00000604428, | |
| Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZNF664 [Title/Abstract] AND AKR1C2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | AKR1C2 | GO:0006693 | prostaglandin metabolic process | 8573067 |
| Tgene | AKR1C2 | GO:0007186 | G-protein coupled receptor signaling pathway | 18508192 |
| Tgene | AKR1C2 | GO:0007586 | digestion | 8573067 |
| Tgene | AKR1C2 | GO:0008202 | steroid metabolic process | 8573067 |
| Tgene | AKR1C2 | GO:0008284 | positive regulation of cell proliferation | 18508192 |
| Tgene | AKR1C2 | GO:0042448 | progesterone metabolic process | 21232532 |
| Tgene | AKR1C2 | GO:0051897 | positive regulation of protein kinase B signaling | 18508192 |
| Tgene | AKR1C2 | GO:0055114 | oxidation-reduction process | 21232532 |
| Tgene | AKR1C2 | GO:0071395 | cellular response to jasmonic acid stimulus | 19487289 |
| Tgene | AKR1C2 | GO:0071799 | cellular response to prostaglandin D stimulus | 18508192 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-OL-A5D7-01A | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000537532 | ENST00000380753 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| intron-intron | ENST00000537532 | ENST00000421196 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| intron-intron | ENST00000537532 | ENST00000407674 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| intron-intron | ENST00000537532 | ENST00000455190 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| intron-intron | ENST00000537532 | ENST00000604428 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000539644 | ENST00000380753 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000539644 | ENST00000421196 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000539644 | ENST00000407674 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000539644 | ENST00000455190 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000539644 | ENST00000604428 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000392404 | ENST00000380753 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000392404 | ENST00000421196 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000392404 | ENST00000407674 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000392404 | ENST00000455190 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000392404 | ENST00000604428 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000538932 | ENST00000380753 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000538932 | ENST00000421196 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000538932 | ENST00000407674 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000538932 | ENST00000455190 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000538932 | ENST00000604428 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000337815 | ENST00000380753 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000337815 | ENST00000421196 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000337815 | ENST00000407674 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000337815 | ENST00000455190 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
| 5CDS-intron | ENST00000337815 | ENST00000604428 | ZNF664 | chr12 | 124497022 | + | AKR1C2 | chr10 | 5048784 | - |
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FusionProtFeatures for ZNF664_AKR1C2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF664 | AKR1C2 |