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Fusion gene ID: 43536 |
FusionGeneSummary for ZNF626_ADI1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF626_ADI1 | Fusion gene ID: 43536 | Hgene | Tgene | Gene symbol | ZNF626 | ADI1 | Gene ID | 199777 | 55256 |
| Gene name | zinc finger protein 626 | acireductone dioxygenase 1 | |
| Synonyms | - | APL1|ARD|Fe-ARD|HMFT1638|MTCBP1|Ni-ARD|SIPL|mtnD | |
| Cytomap | 19p12 | 2p25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 626CTC-513N18.7 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenaseMT1-MMP cytoplasmic tail-binding protein-1acireductone dioxygenase (Fe(2+)-requiring)acireductone dioxygenase (Ni(2+)-requiring)membrane-type 1 matrix metalloproteinase cytoplasmic tail binding prote | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q68DY1 | Q9BV57 | |
| Ensembl transtripts involved in fusion gene | ENST00000601440, ENST00000291750, | ENST00000327435, ENST00000382093, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 5 X 3=60 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/60*10)=0 | |
| Context | PubMed: ZNF626 [Title/Abstract] AND ADI1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ADI1 | GO:0019509 | L-methionine salvage from methylthioadenosine | 15938715 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA351447 | ZNF626 | chr19 | 20844250 | - | ADI1 | chr2 | 3518634 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000601440 | ENST00000327435 | ZNF626 | chr19 | 20844250 | - | ADI1 | chr2 | 3518634 | - |
| 5CDS-intron | ENST00000601440 | ENST00000382093 | ZNF626 | chr19 | 20844250 | - | ADI1 | chr2 | 3518634 | - |
| 5CDS-intron | ENST00000291750 | ENST00000327435 | ZNF626 | chr19 | 20844250 | - | ADI1 | chr2 | 3518634 | - |
| 5CDS-intron | ENST00000291750 | ENST00000382093 | ZNF626 | chr19 | 20844250 | - | ADI1 | chr2 | 3518634 | - |
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FusionProtFeatures for ZNF626_ADI1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF626 | ADI1 |