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Fusion gene ID: 43502 |
FusionGeneSummary for ZNF606_GDAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF606_GDAP1 | Fusion gene ID: 43502 | Hgene | Tgene | Gene symbol | ZNF606 | GDAP1 | Gene ID | 80095 | 54332 |
| Gene name | zinc finger protein 606 | ganglioside induced differentiation associated protein 1 | |
| Synonyms | ZNF328 | CMT4|CMT4A|CMTRIA | |
| Cytomap | 19q13.43 | 8q21.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 606zinc finger protein 328 | ganglioside-induced differentiation-associated protein 1Charcot-Marie-Tooth neuropathy 4A | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8WXB4 | Q8TB36 | |
| Ensembl transtripts involved in fusion gene | ENST00000341164, ENST00000536132, ENST00000552579, ENST00000547828, ENST00000547121, ENST00000546715, | ENST00000521096, ENST00000220822, ENST00000434412, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 1 X 3=9 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF606 [Title/Abstract] AND GDAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GDAP1 | GO:0000266 | mitochondrial fission | 15772096 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-78-7143-01A | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000341164 | ENST00000521096 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| 5CDS-intron | ENST00000341164 | ENST00000220822 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| 5CDS-intron | ENST00000341164 | ENST00000434412 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| 5CDS-intron | ENST00000536132 | ENST00000521096 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| 5CDS-intron | ENST00000536132 | ENST00000220822 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| 5CDS-intron | ENST00000536132 | ENST00000434412 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| intron-intron | ENST00000552579 | ENST00000521096 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| intron-intron | ENST00000552579 | ENST00000220822 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| intron-intron | ENST00000552579 | ENST00000434412 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| intron-intron | ENST00000547828 | ENST00000521096 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| intron-intron | ENST00000547828 | ENST00000220822 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| intron-intron | ENST00000547828 | ENST00000434412 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| intron-intron | ENST00000547121 | ENST00000521096 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| intron-intron | ENST00000547121 | ENST00000220822 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| intron-intron | ENST00000547121 | ENST00000434412 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| intron-intron | ENST00000546715 | ENST00000521096 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| intron-intron | ENST00000546715 | ENST00000220822 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
| intron-intron | ENST00000546715 | ENST00000434412 | ZNF606 | chr19 | 58499575 | - | GDAP1 | chr8 | 75400913 | + |
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FusionProtFeatures for ZNF606_GDAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF606 | GDAP1 |