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Fusion gene ID: 43472

FusionGeneSummary for ZNF585B_MYRIP

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF585B_MYRIP
	Fusion gene ID: 43472
		Hgene	Tgene
	Gene symbol	ZNF585B	MYRIP
	Gene ID	92285	25924
	Gene name	zinc finger protein 585B	myosin VIIA and Rab interacting protein
	Synonyms	SZFP41	SLAC2-C\|SLAC2C
	Cytomap	19q13.12	3p22.1
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 585Bzinc finger protein 41-like protein	rab effector MyRIPSlp homologue lacking C2 domainsexophilin-8myosin-VIIa- and Rab-interacting proteinslp homolog lacking C2 domains csynaptotagmin-like protein homologue lacking C2 domains-csynaptotagmin-like protein lacking C2 domains C
	Modification date	20180519	20180523
	UniProtAcc	Q52M93	Q8NFW9
	Ensembl transtripts involved in fusion gene	ENST00000532828, ENST00000531805, ENST00000312908, ENST00000527838, ENST00000586320, ENST00000534363,	ENST00000444716, ENST00000302541, ENST00000425621, ENST00000396217, ENST00000459828, ENST00000539167,
Fusion gene scores	* DoF score	3 X 1 X 3=9	2 X 2 X 2=8
	# samples	3	2
	** MAII score	log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(2/8*10)=1.32192809488736
Context	PubMed: ZNF585B [Title/Abstract] AND MYRIP [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	STAD	TCGA-BR-7901-01A	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000532828	ENST00000444716	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
In-frame	ENST00000532828	ENST00000302541	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
In-frame	ENST00000532828	ENST00000425621	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
In-frame	ENST00000532828	ENST00000396217	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
5CDS-3UTR	ENST00000532828	ENST00000459828	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
5CDS-3UTR	ENST00000532828	ENST00000539167	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000531805	ENST00000444716	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000531805	ENST00000302541	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000531805	ENST00000425621	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000531805	ENST00000396217	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3UTR	ENST00000531805	ENST00000459828	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3UTR	ENST00000531805	ENST00000539167	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000312908	ENST00000444716	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000312908	ENST00000302541	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000312908	ENST00000425621	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000312908	ENST00000396217	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3UTR	ENST00000312908	ENST00000459828	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3UTR	ENST00000312908	ENST00000539167	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
In-frame	ENST00000527838	ENST00000444716	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
In-frame	ENST00000527838	ENST00000302541	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
In-frame	ENST00000527838	ENST00000425621	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
In-frame	ENST00000527838	ENST00000396217	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
5CDS-3UTR	ENST00000527838	ENST00000459828	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
5CDS-3UTR	ENST00000527838	ENST00000539167	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000586320	ENST00000444716	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000586320	ENST00000302541	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000586320	ENST00000425621	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000586320	ENST00000396217	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3UTR	ENST00000586320	ENST00000459828	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3UTR	ENST00000586320	ENST00000539167	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000534363	ENST00000444716	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000534363	ENST00000302541	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000534363	ENST00000425621	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3CDS	ENST00000534363	ENST00000396217	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3UTR	ENST00000534363	ENST00000459828	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+
intron-3UTR	ENST00000534363	ENST00000539167	ZNF585B	chr19	37697942	-	MYRIP	chr3	40223711	+

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FusionProtFeatures for ZNF585B_MYRIP

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZNF585B Q52M93	MYRIP Q8NFW9

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Fusion gene ID: 43472

FusionGeneSummary for ZNF585B_MYRIP

FusionProtFeatures for ZNF585B_MYRIP