FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 43406

FusionGeneSummary for ZNF532_NEDD4L

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF532_NEDD4L
Fusion gene ID: 43406
HgeneTgene
Gene symbol

ZNF532

NEDD4L

Gene ID

55205

23327

Gene namezinc finger protein 532neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Synonyms-NEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2
Cytomap

18q21.32

18q21.31

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 532E3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lubiquitin-protein ligase Rsp5
Modification date2018052220180523
UniProtAcc

Q9HCE3

Q96PU5

Ensembl transtripts involved in fusion geneENST00000336078, ENST00000591083, 
ENST00000589288, ENST00000591230, 
ENST00000591808, ENST00000588956, 
ENST00000356462, ENST00000400345, 
ENST00000589054, ENST00000256832, 
ENST00000382850, ENST00000256830, 
ENST00000588516, ENST00000456986, 
ENST00000435432, ENST00000357895, 
ENST00000586263, ENST00000456173, 
ENST00000431212, 
Fusion gene scores* DoF score5 X 6 X 6=18013 X 14 X 6=1092
# samples 816
** MAII scorelog2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/1092*10)=-2.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF532 [Title/Abstract] AND NEDD4L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNEDD4L

GO:0003254

regulation of membrane depolarization

15217910

TgeneNEDD4L

GO:0006511

ubiquitin-dependent protein catabolic process

21463633

TgeneNEDD4L

GO:0010038

response to metal ion

11244092

TgeneNEDD4L

GO:0016567

protein ubiquitination

15217910|25631046

TgeneNEDD4L

GO:0034765

regulation of ion transmembrane transport

17289006

TgeneNEDD4L

GO:0042391

regulation of membrane potential

17289006

TgeneNEDD4L

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

21463633

TgeneNEDD4L

GO:0060306

regulation of membrane repolarization

21463633

TgeneNEDD4L

GO:0070936

protein K48-linked ubiquitination

21463633

TgeneNEDD4L

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

TgeneNEDD4L

GO:1901017

negative regulation of potassium ion transmembrane transporter activity

21463633

TgeneNEDD4L

GO:1901380

negative regulation of potassium ion transmembrane transport

21463633

TgeneNEDD4L

GO:1902306

negative regulation of sodium ion transmembrane transport

15217910

TgeneNEDD4L

GO:1903861

positive regulation of dendrite extension

23999003

TgeneNEDD4L

GO:2000009

negative regulation of protein localization to cell surface

21463633

TgeneNEDD4L

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

15217910


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-KK-A8ID-01AZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
TCGALDUCECTCGA-AJ-A3BF-01AZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000336078ENST00000356462ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
In-frameENST00000336078ENST00000400345ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000336078ENST00000589054ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000336078ENST00000256832ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000336078ENST00000382850ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000336078ENST00000256830ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-3UTRENST00000336078ENST00000588516ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000336078ENST00000456986ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000336078ENST00000435432ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000336078ENST00000357895ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000336078ENST00000586263ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000336078ENST00000456173ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000336078ENST00000431212ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
In-frameENST00000591083ENST00000356462ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
In-frameENST00000591083ENST00000400345ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000591083ENST00000589054ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591083ENST00000256832ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591083ENST00000382850ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591083ENST00000256830ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-3UTRENST00000591083ENST00000588516ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591083ENST00000456986ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591083ENST00000435432ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591083ENST00000357895ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591083ENST00000586263ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000591083ENST00000456173ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000591083ENST00000431212ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
In-frameENST00000589288ENST00000356462ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
In-frameENST00000589288ENST00000400345ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000589288ENST00000589054ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000589288ENST00000256832ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000589288ENST00000382850ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000589288ENST00000256830ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-3UTRENST00000589288ENST00000588516ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000589288ENST00000456986ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000589288ENST00000435432ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000589288ENST00000357895ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000589288ENST00000586263ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000589288ENST00000456173ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000589288ENST00000431212ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
In-frameENST00000591230ENST00000356462ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
In-frameENST00000591230ENST00000400345ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000591230ENST00000589054ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591230ENST00000256832ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591230ENST00000382850ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591230ENST00000256830ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-3UTRENST00000591230ENST00000588516ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591230ENST00000456986ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591230ENST00000435432ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591230ENST00000357895ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591230ENST00000586263ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000591230ENST00000456173ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000591230ENST00000431212ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
In-frameENST00000591808ENST00000356462ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
In-frameENST00000591808ENST00000400345ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000591808ENST00000589054ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591808ENST00000256832ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591808ENST00000382850ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591808ENST00000256830ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-3UTRENST00000591808ENST00000588516ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591808ENST00000456986ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591808ENST00000435432ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591808ENST00000357895ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-5UTRENST00000591808ENST00000586263ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000591808ENST00000456173ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
5CDS-intronENST00000591808ENST00000431212ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-3CDSENST00000588956ENST00000356462ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-3CDSENST00000588956ENST00000400345ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-intronENST00000588956ENST00000589054ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000588956ENST00000256832ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000588956ENST00000382850ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000588956ENST00000256830ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-3UTRENST00000588956ENST00000588516ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000588956ENST00000456986ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000588956ENST00000435432ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000588956ENST00000357895ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-5UTRENST00000588956ENST00000586263ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-intronENST00000588956ENST00000456173ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
intron-intronENST00000588956ENST00000431212ZNF532chr18

56587865

+NEDD4Lchr18

55833020

+
In-frameENST00000336078ENST00000356462ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
In-frameENST00000336078ENST00000400345ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000336078ENST00000589054ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000336078ENST00000256832ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000336078ENST00000382850ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000336078ENST00000256830ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000336078ENST00000588516ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000336078ENST00000456986ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000336078ENST00000435432ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000336078ENST00000357895ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000336078ENST00000586263ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000336078ENST00000456173ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000336078ENST00000431212ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
In-frameENST00000591083ENST00000356462ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
In-frameENST00000591083ENST00000400345ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591083ENST00000589054ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591083ENST00000256832ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591083ENST00000382850ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591083ENST00000256830ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591083ENST00000588516ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591083ENST00000456986ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591083ENST00000435432ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591083ENST00000357895ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591083ENST00000586263ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591083ENST00000456173ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591083ENST00000431212ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
In-frameENST00000589288ENST00000356462ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
In-frameENST00000589288ENST00000400345ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000589288ENST00000589054ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000589288ENST00000256832ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000589288ENST00000382850ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000589288ENST00000256830ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000589288ENST00000588516ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000589288ENST00000456986ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000589288ENST00000435432ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000589288ENST00000357895ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000589288ENST00000586263ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000589288ENST00000456173ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000589288ENST00000431212ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
In-frameENST00000591230ENST00000356462ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
In-frameENST00000591230ENST00000400345ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591230ENST00000589054ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591230ENST00000256832ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591230ENST00000382850ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591230ENST00000256830ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591230ENST00000588516ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591230ENST00000456986ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591230ENST00000435432ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591230ENST00000357895ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591230ENST00000586263ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591230ENST00000456173ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591230ENST00000431212ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
In-frameENST00000591808ENST00000356462ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
In-frameENST00000591808ENST00000400345ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591808ENST00000589054ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591808ENST00000256832ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591808ENST00000382850ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591808ENST00000256830ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591808ENST00000588516ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591808ENST00000456986ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591808ENST00000435432ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591808ENST00000357895ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591808ENST00000586263ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591808ENST00000456173ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
5CDS-intronENST00000591808ENST00000431212ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-3CDSENST00000588956ENST00000356462ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-3CDSENST00000588956ENST00000400345ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-intronENST00000588956ENST00000589054ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-intronENST00000588956ENST00000256832ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-intronENST00000588956ENST00000382850ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-intronENST00000588956ENST00000256830ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-intronENST00000588956ENST00000588516ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-intronENST00000588956ENST00000456986ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-intronENST00000588956ENST00000435432ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-intronENST00000588956ENST00000357895ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-intronENST00000588956ENST00000586263ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-intronENST00000588956ENST00000456173ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+
intron-intronENST00000588956ENST00000431212ZNF532chr18

56585954

+NEDD4Lchr18

56018223

+

Top

FusionProtFeatures for ZNF532_NEDD4L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZNF532

Q9HCE3

NEDD4L

Q96PU5