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Fusion gene ID: 43366

FusionGeneSummary for ZNF493_RPL13A

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF493_RPL13A
	Fusion gene ID: 43366
		Hgene	Tgene
	Gene symbol	ZNF493	RPL13A
	Gene ID	284443	23521
	Gene name	zinc finger protein 493	ribosomal protein L13a
	Synonyms	-	L13A\|TSTA1
	Cytomap	19p12	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 493	60S ribosomal protein L13a23 kDa highly basic proteinlarge ribosomal subunit protein uL13tissue specific transplantation antigen 1
	Modification date	20180403	20180523
	UniProtAcc	Q6ZR52	P40429
	Ensembl transtripts involved in fusion gene	ENST00000596302, ENST00000392288, ENST00000594390, ENST00000355504, ENST00000339914, ENST00000599461,	ENST00000391857, ENST00000477613,
Fusion gene scores	* DoF score	2 X 2 X 2=8	5 X 5 X 4=100
	# samples	2	5
	** MAII score	log2(2/8*10)=1.32192809488736	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF493 [Title/Abstract] AND RPL13A [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RPL13A	GO:0017148	negative regulation of translation	14567916\|23071094
Tgene	RPL13A	GO:0071346	cellular response to interferon-gamma	15479637
Tgene	RPL13A	GO:1901194	negative regulation of formation of translation preinitiation complex	17218275

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	PAAD	TCGA-US-A776-01A	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000596302	ENST00000391857	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+
5CDS-3UTR	ENST00000596302	ENST00000477613	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+
In-frame	ENST00000392288	ENST00000391857	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+
5CDS-3UTR	ENST00000392288	ENST00000477613	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+
In-frame	ENST00000594390	ENST00000391857	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+
5CDS-3UTR	ENST00000594390	ENST00000477613	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+
5UTR-3CDS	ENST00000355504	ENST00000391857	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+
5UTR-3UTR	ENST00000355504	ENST00000477613	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+
In-frame	ENST00000339914	ENST00000391857	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+
5CDS-3UTR	ENST00000339914	ENST00000477613	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+
Frame-shift	ENST00000599461	ENST00000391857	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+
5CDS-3UTR	ENST00000599461	ENST00000477613	ZNF493	chr19	21580069	+	RPL13A	chr19	49993107	+

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FusionProtFeatures for ZNF493_RPL13A

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZNF493 Q6ZR52	RPL13A P40429

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Fusion gene ID: 43366

FusionGeneSummary for ZNF493_RPL13A

FusionProtFeatures for ZNF493_RPL13A