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Fusion gene ID: 43329 |
FusionGeneSummary for ZNF440_ECSIT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF440_ECSIT | Fusion gene ID: 43329 | Hgene | Tgene | Gene symbol | ZNF440 | ECSIT | Gene ID | 126070 | 51295 |
| Gene name | zinc finger protein 440 | ECSIT signalling integrator | |
| Synonyms | - | SITPEC | |
| Cytomap | 19p13.2 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 440 | evolutionarily conserved signaling intermediate in Toll pathway, mitochondrialECSIT homologlikely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8IYI8 | Q9BQ95 | |
| Ensembl transtripts involved in fusion gene | ENST00000304060, | ENST00000270517, ENST00000588998, ENST00000252440, ENST00000417981, ENST00000591104, ENST00000592312, ENST00000591352, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 3 X 3=36 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF440 [Title/Abstract] AND ECSIT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ECSIT | GO:0051341 | regulation of oxidoreductase activity | 17344420 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UVM | TCGA-VD-AA8M-01A | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000304060 | ENST00000270517 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| In-frame | ENST00000304060 | ENST00000588998 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| In-frame | ENST00000304060 | ENST00000252440 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| In-frame | ENST00000304060 | ENST00000417981 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| In-frame | ENST00000304060 | ENST00000591104 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| In-frame | ENST00000304060 | ENST00000592312 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
| 5CDS-5UTR | ENST00000304060 | ENST00000591352 | ZNF440 | chr19 | 11925265 | + | ECSIT | chr19 | 11618863 | - |
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FusionProtFeatures for ZNF440_ECSIT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF440 | ECSIT |