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Fusion gene ID: 43328 |
FusionGeneSummary for ZNF43_EFHB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF43_EFHB | Fusion gene ID: 43328 | Hgene | Tgene | Gene symbol | ZNF43 | EFHB | Gene ID | 7594 | 151651 |
| Gene name | zinc finger protein 43 | EF-hand domain family member B | |
| Synonyms | HTF6|KOX27|ZNF39L1 | CFAP21 | |
| Cytomap | 19p12 | 3p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 43zinc finger protein 39-like 1 (KOX 27)zinc finger protein HTF6zinc finger protein KOX27 | EF-hand domain-containing family member Bcilia and flagella associated protein 21 | |
| Modification date | 20180403 | 20180403 | |
| UniProtAcc | P17038 | Q8N7U6 | |
| Ensembl transtripts involved in fusion gene | ENST00000594012, ENST00000595461, ENST00000598381, ENST00000598288, ENST00000354959, ENST00000599414, | ENST00000295824, ENST00000344838, ENST00000498089, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 1 X 2 X 1=2 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/2*10)=2.32192809488736 | |
| Context | PubMed: ZNF43 [Title/Abstract] AND EFHB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-5508-01A | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| TCGA | LD | PRAD | TCGA-EJ-5508-01A | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000594012 | ENST00000295824 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-5UTR | ENST00000594012 | ENST00000344838 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-intron | ENST00000594012 | ENST00000498089 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-intron | ENST00000595461 | ENST00000295824 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-5UTR | ENST00000595461 | ENST00000344838 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-intron | ENST00000595461 | ENST00000498089 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-intron | ENST00000598381 | ENST00000295824 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-5UTR | ENST00000598381 | ENST00000344838 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-intron | ENST00000598381 | ENST00000498089 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-intron | ENST00000598288 | ENST00000295824 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-5UTR | ENST00000598288 | ENST00000344838 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-intron | ENST00000598288 | ENST00000498089 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| 5CDS-intron | ENST00000354959 | ENST00000295824 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| 5CDS-5UTR | ENST00000354959 | ENST00000344838 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| 5CDS-intron | ENST00000354959 | ENST00000498089 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-intron | ENST00000599414 | ENST00000295824 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-5UTR | ENST00000599414 | ENST00000344838 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| intron-intron | ENST00000599414 | ENST00000498089 | ZNF43 | chr19 | 22018838 | - | EFHB | chr3 | 19977826 | - |
| 5UTR-3CDS | ENST00000594012 | ENST00000295824 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| 5UTR-3CDS | ENST00000594012 | ENST00000344838 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| 5UTR-5UTR | ENST00000594012 | ENST00000498089 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| 5UTR-3CDS | ENST00000595461 | ENST00000295824 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| 5UTR-3CDS | ENST00000595461 | ENST00000344838 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| 5UTR-5UTR | ENST00000595461 | ENST00000498089 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| intron-3CDS | ENST00000598381 | ENST00000295824 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| intron-3CDS | ENST00000598381 | ENST00000344838 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| intron-5UTR | ENST00000598381 | ENST00000498089 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| intron-3CDS | ENST00000598288 | ENST00000295824 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| intron-3CDS | ENST00000598288 | ENST00000344838 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| intron-5UTR | ENST00000598288 | ENST00000498089 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| intron-3CDS | ENST00000354959 | ENST00000295824 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| intron-3CDS | ENST00000354959 | ENST00000344838 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| intron-5UTR | ENST00000354959 | ENST00000498089 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| intron-3CDS | ENST00000599414 | ENST00000295824 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| intron-3CDS | ENST00000599414 | ENST00000344838 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
| intron-5UTR | ENST00000599414 | ENST00000498089 | ZNF43 | chr19 | 22033740 | - | EFHB | chr3 | 19962059 | - |
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FusionProtFeatures for ZNF43_EFHB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF43 | EFHB |