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Fusion gene ID: 43316

FusionGeneSummary for ZNF431_EPS15L1

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF431_EPS15L1
	Fusion gene ID: 43316
		Hgene	Tgene
	Gene symbol	ZNF431	EPS15L1
	Gene ID	170959	58513
	Gene name	zinc finger protein 431	epidermal growth factor receptor pathway substrate 15 like 1
	Synonyms	-	EPS15R
	Cytomap	19p12	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 431	epidermal growth factor receptor substrate 15-like 1epidermal growth factor receptor substrate EPS15Reps15-related protein
	Modification date	20180519	20180522
	UniProtAcc	Q8TF32	Q9UBC2
	Ensembl transtripts involved in fusion gene	ENST00000600692, ENST00000599296, ENST00000594425, ENST00000311048, ENST00000594821,	ENST00000455140, ENST00000248070, ENST00000535753, ENST00000594975, ENST00000602009, ENST00000597937,
Fusion gene scores	* DoF score	3 X 1 X 2=6	10 X 8 X 5=400
	# samples	3	9
	** MAII score	log2(3/6*10)=2.32192809488736	log2(9/400*10)=-2.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF431 [Title/Abstract] AND EPS15L1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SARC	TCGA-X6-A7WC-01A	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000600692	ENST00000455140	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000600692	ENST00000248070	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000600692	ENST00000535753	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000600692	ENST00000594975	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000600692	ENST00000602009	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000600692	ENST00000597937	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000599296	ENST00000455140	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000599296	ENST00000248070	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000599296	ENST00000535753	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000599296	ENST00000594975	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000599296	ENST00000602009	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000599296	ENST00000597937	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000594425	ENST00000455140	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000594425	ENST00000248070	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000594425	ENST00000535753	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000594425	ENST00000594975	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000594425	ENST00000602009	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000594425	ENST00000597937	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000311048	ENST00000455140	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000311048	ENST00000248070	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000311048	ENST00000535753	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000311048	ENST00000594975	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000311048	ENST00000602009	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
In-frame	ENST00000311048	ENST00000597937	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
intron-3CDS	ENST00000594821	ENST00000455140	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
intron-3CDS	ENST00000594821	ENST00000248070	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
intron-3CDS	ENST00000594821	ENST00000535753	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
intron-3CDS	ENST00000594821	ENST00000594975	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
intron-3CDS	ENST00000594821	ENST00000602009	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-
intron-3CDS	ENST00000594821	ENST00000597937	ZNF431	chr19	21326446	+	EPS15L1	chr19	16528448	-

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FusionProtFeatures for ZNF431_EPS15L1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZNF431 Q8TF32	EPS15L1 Q9UBC2

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Fusion gene ID: 43316

FusionGeneSummary for ZNF431_EPS15L1

FusionProtFeatures for ZNF431_EPS15L1