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Fusion gene ID: 43313 |
FusionGeneSummary for ZNF430_GABRB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF430_GABRB1 | Fusion gene ID: 43313 | Hgene | Tgene | Gene symbol | ZNF430 | GABRB1 | Gene ID | 80264 | 2560 |
| Gene name | zinc finger protein 430 | gamma-aminobutyric acid type A receptor beta1 subunit | |
| Synonyms | - | EIEE45 | |
| Cytomap | 19p12 | 4p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 430 | gamma-aminobutyric acid receptor subunit beta-1gamma-aminobutyric acid (GABA) A receptor, beta 1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9H8G1 | P18505 | |
| Ensembl transtripts involved in fusion gene | ENST00000261560, ENST00000599548, ENST00000595401, | ENST00000295454, ENST00000538619, ENST00000509366, | |
| Fusion gene scores | * DoF score | 5 X 2 X 4=40 | 5 X 2 X 4=40 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF430 [Title/Abstract] AND GABRB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GABRB1 | GO:1902476 | chloride transmembrane transport | 9039914 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-34-5241-01A | ZNF430 | chr19 | 21216990 | + | GABRB1 | chr4 | 47033931 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000261560 | ENST00000295454 | ZNF430 | chr19 | 21216990 | + | GABRB1 | chr4 | 47033931 | + |
| 5CDS-5UTR | ENST00000261560 | ENST00000538619 | ZNF430 | chr19 | 21216990 | + | GABRB1 | chr4 | 47033931 | + |
| 5CDS-3UTR | ENST00000261560 | ENST00000509366 | ZNF430 | chr19 | 21216990 | + | GABRB1 | chr4 | 47033931 | + |
| Frame-shift | ENST00000599548 | ENST00000295454 | ZNF430 | chr19 | 21216990 | + | GABRB1 | chr4 | 47033931 | + |
| 5CDS-5UTR | ENST00000599548 | ENST00000538619 | ZNF430 | chr19 | 21216990 | + | GABRB1 | chr4 | 47033931 | + |
| 5CDS-3UTR | ENST00000599548 | ENST00000509366 | ZNF430 | chr19 | 21216990 | + | GABRB1 | chr4 | 47033931 | + |
| Frame-shift | ENST00000595401 | ENST00000295454 | ZNF430 | chr19 | 21216990 | + | GABRB1 | chr4 | 47033931 | + |
| 5CDS-5UTR | ENST00000595401 | ENST00000538619 | ZNF430 | chr19 | 21216990 | + | GABRB1 | chr4 | 47033931 | + |
| 5CDS-3UTR | ENST00000595401 | ENST00000509366 | ZNF430 | chr19 | 21216990 | + | GABRB1 | chr4 | 47033931 | + |
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FusionProtFeatures for ZNF430_GABRB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF430 | GABRB1 |