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Fusion gene ID: 43312 |
FusionGeneSummary for ZNF430_CD19 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF430_CD19 | Fusion gene ID: 43312 | Hgene | Tgene | Gene symbol | ZNF430 | CD19 | Gene ID | 80264 | 930 |
| Gene name | zinc finger protein 430 | CD19 molecule | |
| Synonyms | - | B4|CVID3 | |
| Cytomap | 19p12 | 16p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 430 | B-lymphocyte antigen CD19B-lymphocyte surface antigen B4T-cell surface antigen Leu-12differentiation antigen CD19 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9H8G1 | P15391 | |
| Ensembl transtripts involved in fusion gene | ENST00000261560, ENST00000599548, ENST00000595401, | ENST00000538922, ENST00000324662, ENST00000567541, | |
| Fusion gene scores | * DoF score | 5 X 2 X 4=40 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZNF430 [Title/Abstract] AND CD19 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-GV-A3JW-01A | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000261560 | ENST00000538922 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
| Frame-shift | ENST00000261560 | ENST00000324662 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
| Frame-shift | ENST00000261560 | ENST00000567541 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
| Frame-shift | ENST00000599548 | ENST00000538922 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
| Frame-shift | ENST00000599548 | ENST00000324662 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
| Frame-shift | ENST00000599548 | ENST00000567541 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
| Frame-shift | ENST00000595401 | ENST00000538922 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
| Frame-shift | ENST00000595401 | ENST00000324662 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
| Frame-shift | ENST00000595401 | ENST00000567541 | ZNF430 | chr19 | 21205687 | + | CD19 | chr16 | 28944232 | + |
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FusionProtFeatures for ZNF430_CD19 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF430 | CD19 |