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Fusion gene ID: 4329 |
FusionGeneSummary for BPIFB1_SNAPC5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BPIFB1_SNAPC5 | Fusion gene ID: 4329 | Hgene | Tgene | Gene symbol | BPIFB1 | SNAPC5 | Gene ID | 92747 | 10302 |
| Gene name | BPI fold containing family B member 1 | small nuclear RNA activating complex polypeptide 5 | |
| Synonyms | C20orf114|LPLUNC1 | SNAP19 | |
| Cytomap | 20q11.21 | 15q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | BPI fold-containing family B member 1VEMSGPlong palate, lung and nasal epithelium carcinoma associated 1long palate, lung and nasal epithelium carcinoma-associated protein 1von Ebner minor salivary gland protein | snRNA-activating protein complex subunit 5SNAPc 19 kDa subunitSNAPc subunit 5snRNA-activating protein complex 19 kDa subunit | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8TDL5 | O75971 | |
| Ensembl transtripts involved in fusion gene | ENST00000253354, ENST00000464032, | ENST00000563480, ENST00000395589, ENST00000316634, ENST00000307979, ENST00000566658, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: BPIFB1 [Title/Abstract] AND SNAPC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BPIFB1 | GO:0002227 | innate immune response in mucosa | 21900486 |
| Hgene | BPIFB1 | GO:0034144 | negative regulation of toll-like receptor 4 signaling pathway | 21900486 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A14V-01A | BPIFB1 | chr20 | 31879794 | + | SNAPC5 | chr15 | 66787757 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000253354 | ENST00000563480 | BPIFB1 | chr20 | 31879794 | + | SNAPC5 | chr15 | 66787757 | - |
| In-frame | ENST00000253354 | ENST00000395589 | BPIFB1 | chr20 | 31879794 | + | SNAPC5 | chr15 | 66787757 | - |
| In-frame | ENST00000253354 | ENST00000316634 | BPIFB1 | chr20 | 31879794 | + | SNAPC5 | chr15 | 66787757 | - |
| 5CDS-intron | ENST00000253354 | ENST00000307979 | BPIFB1 | chr20 | 31879794 | + | SNAPC5 | chr15 | 66787757 | - |
| 5CDS-intron | ENST00000253354 | ENST00000566658 | BPIFB1 | chr20 | 31879794 | + | SNAPC5 | chr15 | 66787757 | - |
| intron-3CDS | ENST00000464032 | ENST00000563480 | BPIFB1 | chr20 | 31879794 | + | SNAPC5 | chr15 | 66787757 | - |
| intron-3CDS | ENST00000464032 | ENST00000395589 | BPIFB1 | chr20 | 31879794 | + | SNAPC5 | chr15 | 66787757 | - |
| intron-3CDS | ENST00000464032 | ENST00000316634 | BPIFB1 | chr20 | 31879794 | + | SNAPC5 | chr15 | 66787757 | - |
| intron-intron | ENST00000464032 | ENST00000307979 | BPIFB1 | chr20 | 31879794 | + | SNAPC5 | chr15 | 66787757 | - |
| intron-intron | ENST00000464032 | ENST00000566658 | BPIFB1 | chr20 | 31879794 | + | SNAPC5 | chr15 | 66787757 | - |
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FusionProtFeatures for BPIFB1_SNAPC5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BPIFB1 | SNAPC5 |