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Fusion gene ID: 43266 |
FusionGeneSummary for ZNF398_PARG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF398_PARG | Fusion gene ID: 43266 | Hgene | Tgene | Gene symbol | ZNF398 | PARG | Gene ID | 57541 | 8505 |
| Gene name | zinc finger protein 398 | poly(ADP-ribose) glycohydrolase | |
| Synonyms | P51|P71|ZER6 | PARG99 | |
| Cytomap | 7q36.1 | 10q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 398zinc finger DNA binding protein ZER6zinc finger DNA binding protein p52/p71zinc finger-estrogen receptor interaction, clone 6 | poly(ADP-ribose) glycohydrolasemitochondrial poly(ADP-ribose) glycohydrolasepoly(ADP-ribose) glycohydrolase 60 kDa isoform | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8TD17 | Q86W56 | |
| Ensembl transtripts involved in fusion gene | ENST00000426851, ENST00000485111, ENST00000420008, ENST00000475153, ENST00000483892, ENST00000491174, ENST00000540950, ENST00000335901, | ENST00000402038, ENST00000492350, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 7 X 6 X 4=168 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZNF398 [Title/Abstract] AND PARG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PARG | GO:1990966 | ATP generation from poly-ADP-D-ribose | 27257257 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF899538 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000426851 | ENST00000402038 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000426851 | ENST00000492350 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000485111 | ENST00000402038 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000485111 | ENST00000492350 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000420008 | ENST00000402038 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000420008 | ENST00000492350 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000475153 | ENST00000402038 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000475153 | ENST00000492350 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000483892 | ENST00000402038 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000483892 | ENST00000492350 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000491174 | ENST00000402038 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000491174 | ENST00000492350 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000540950 | ENST00000402038 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000540950 | ENST00000492350 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000335901 | ENST00000402038 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
| intron-intron | ENST00000335901 | ENST00000492350 | ZNF398 | chr7 | 148858349 | - | PARG | chr10 | 51127287 | - |
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FusionProtFeatures for ZNF398_PARG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF398 | PARG |