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Fusion gene ID: 43252 |
FusionGeneSummary for ZNF384_SDR16C5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF384_SDR16C5 | Fusion gene ID: 43252 | Hgene | Tgene | Gene symbol | ZNF384 | SDR16C5 | Gene ID | 171017 | 195814 |
| Gene name | zinc finger protein 384 | short chain dehydrogenase/reductase family 16C member 5 | |
| Synonyms | CAGH1|CAGH1A|CIZ|ERDA2|NMP4|NP|TNRC1 | EPHD-2|RDH#2|RDH-E2|RDHE2|retSDR2 | |
| Cytomap | 12p13.31 | 8q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 384CAG repeat protein 1Cas-interacting zinc finger proteinexpanded repeat domain, CAG/CTG 2nuclear matrix transcription factor 4trinucleotide repeat-containing gene 1 protein | epidermal retinol dehydrogenase 2epidermal retinal dehydrogenase 2retinal short chain dehydrogenase reductaseretinal short-chain dehydrogenase reductase 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8TF68 | Q8N3Y7 | |
| Ensembl transtripts involved in fusion gene | ENST00000396795, ENST00000319770, ENST00000396801, ENST00000361959, ENST00000355772, ENST00000396799, | ENST00000396721, ENST00000303749, ENST00000522671, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZNF384 [Title/Abstract] AND SDR16C5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SDR16C5 | GO:0031065 | positive regulation of histone deacetylation | 16691198 |
| Tgene | SDR16C5 | GO:0035067 | negative regulation of histone acetylation | 16691198 |
| Tgene | SDR16C5 | GO:0042572 | retinol metabolic process | 18926804|19102727 |
| Tgene | SDR16C5 | GO:0042574 | retinal metabolic process | 18926804|19102727 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE464107 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000396795 | ENST00000396721 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000396795 | ENST00000303749 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000396795 | ENST00000522671 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-3UTR | ENST00000319770 | ENST00000396721 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000319770 | ENST00000303749 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000319770 | ENST00000522671 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-3UTR | ENST00000396801 | ENST00000396721 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000396801 | ENST00000303749 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000396801 | ENST00000522671 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-3UTR | ENST00000361959 | ENST00000396721 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000361959 | ENST00000303749 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000361959 | ENST00000522671 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-3UTR | ENST00000355772 | ENST00000396721 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000355772 | ENST00000303749 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000355772 | ENST00000522671 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-3UTR | ENST00000396799 | ENST00000396721 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000396799 | ENST00000303749 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
| intron-intron | ENST00000396799 | ENST00000522671 | ZNF384 | chr12 | 6776259 | + | SDR16C5 | chr8 | 57213284 | + |
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FusionProtFeatures for ZNF384_SDR16C5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF384 | SDR16C5 |