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Fusion gene ID: 43192

FusionGeneSummary for ZNF311_TTBK1

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF311_TTBK1
	Fusion gene ID: 43192
		Hgene	Tgene
	Gene symbol	ZNF311	TTBK1
	Gene ID	282890	84630
	Gene name	zinc finger protein 311	tau tubulin kinase 1
	Synonyms	zf31	BDTK
	Cytomap	6p22.1	6p21.1
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 311zinc finger protein zfp31	tau-tubulin kinase 1brain-derived tau kinase
	Modification date	20180522	20180523
	UniProtAcc	Q5JNZ3	Q5TCY1
	Ensembl transtripts involved in fusion gene	ENST00000377179, ENST00000483450, ENST00000426120, ENST00000481554, ENST00000487312, ENST00000452316, ENST00000429714, ENST00000466714, ENST00000383655, ENST00000474196, ENST00000436574, ENST00000490260, ENST00000458265, ENST00000484052,	ENST00000259750, ENST00000304139,
Fusion gene scores	* DoF score	1 X 1 X 1=1	3 X 3 X 3=27
	# samples	1	3
	** MAII score	log2(1/1*10)=3.32192809488736	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ZNF311 [Title/Abstract] AND TTBK1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TTBK1	GO:0018105	peptidyl-serine phosphorylation	16923168
Tgene	TTBK1	GO:0018107	peptidyl-threonine phosphorylation	16923168
Tgene	TTBK1	GO:0018108	peptidyl-tyrosine phosphorylation	16923168
Tgene	TTBK1	GO:0032273	positive regulation of protein polymerization	16923168

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	CHOL	TCGA-3X-AAVC-01A	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000377179	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
5CDS-intron	ENST00000377179	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
5UTR-intron	ENST00000483450	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
5UTR-intron	ENST00000483450	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000426120	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000426120	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000481554	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000481554	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000487312	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000487312	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000452316	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000452316	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000429714	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000429714	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000466714	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000466714	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000383655	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000383655	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000474196	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000474196	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000436574	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000436574	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000490260	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000490260	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000458265	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000458265	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000484052	ENST00000259750	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+
intron-intron	ENST00000484052	ENST00000304139	ZNF311	chr6	28966511	-	TTBK1	chr6	43237381	+

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FusionProtFeatures for ZNF311_TTBK1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZNF311 Q5JNZ3	TTBK1 Q5TCY1

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Fusion gene ID: 43192

FusionGeneSummary for ZNF311_TTBK1

FusionProtFeatures for ZNF311_TTBK1