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Fusion gene ID: 43089 |
FusionGeneSummary for ZNF217_RSBN1L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF217_RSBN1L | Fusion gene ID: 43089 | Hgene | Tgene | Gene symbol | ZNF217 | RSBN1L | Gene ID | 7764 | 222194 |
| Gene name | zinc finger protein 217 | round spermatid basic protein 1 like | |
| Synonyms | ZABC1 | - | |
| Cytomap | 20q13.2 | 7q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 217 | round spermatid basic protein 1-like protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O75362 | Q6PCB5 | |
| Ensembl transtripts involved in fusion gene | ENST00000371471, ENST00000302342, ENST00000540425, | ENST00000334955, ENST00000445288, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 2 X 2 X 2=8 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ZNF217 [Title/Abstract] AND RSBN1L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZNF217 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 17130829 |
| Hgene | ZNF217 | GO:0006355 | regulation of transcription, DNA-templated | 18625718 |
| Hgene | ZNF217 | GO:0045892 | negative regulation of transcription, DNA-templated | 16940172 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW794844 | ZNF217 | chr20 | 52184202 | + | RSBN1L | chr7 | 77346637 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000371471 | ENST00000334955 | ZNF217 | chr20 | 52184202 | + | RSBN1L | chr7 | 77346637 | - |
| intron-intron | ENST00000371471 | ENST00000445288 | ZNF217 | chr20 | 52184202 | + | RSBN1L | chr7 | 77346637 | - |
| intron-intron | ENST00000302342 | ENST00000334955 | ZNF217 | chr20 | 52184202 | + | RSBN1L | chr7 | 77346637 | - |
| intron-intron | ENST00000302342 | ENST00000445288 | ZNF217 | chr20 | 52184202 | + | RSBN1L | chr7 | 77346637 | - |
| intron-intron | ENST00000540425 | ENST00000334955 | ZNF217 | chr20 | 52184202 | + | RSBN1L | chr7 | 77346637 | - |
| intron-intron | ENST00000540425 | ENST00000445288 | ZNF217 | chr20 | 52184202 | + | RSBN1L | chr7 | 77346637 | - |
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FusionProtFeatures for ZNF217_RSBN1L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF217 | RSBN1L |