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Fusion gene ID: 43035 |
FusionGeneSummary for ZNF14_STAT5A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZNF14_STAT5A | Fusion gene ID: 43035 | Hgene | Tgene | Gene symbol | ZNF14 | STAT5A | Gene ID | 7561 | 6776 |
| Gene name | zinc finger protein 14 | signal transducer and activator of transcription 5A | |
| Synonyms | GIOT-4|KOX6 | MGF|STAT5 | |
| Cytomap | 19p13.11 | 17q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger protein 14gonadotropin inducible transcription repressor-4gonadotropin-inducible ovary transcription repressor 4zinc finger protein 14 (KOX 6)zinc finger protein KOX6 | signal transducer and activator of transcription 5A | |
| Modification date | 20180403 | 20180522 | |
| UniProtAcc | P17017 | P42229 | |
| Ensembl transtripts involved in fusion gene | ENST00000344099, | ENST00000345506, ENST00000590949, ENST00000546010, ENST00000452307, ENST00000588868, ENST00000587646, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 3 X 3=27 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZNF14 [Title/Abstract] AND STAT5A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-86-7953-01A | ZNF14 | chr19 | 19843765 | - | STAT5A | chr17 | 40447637 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000344099 | ENST00000345506 | ZNF14 | chr19 | 19843765 | - | STAT5A | chr17 | 40447637 | + |
| In-frame | ENST00000344099 | ENST00000590949 | ZNF14 | chr19 | 19843765 | - | STAT5A | chr17 | 40447637 | + |
| In-frame | ENST00000344099 | ENST00000546010 | ZNF14 | chr19 | 19843765 | - | STAT5A | chr17 | 40447637 | + |
| In-frame | ENST00000344099 | ENST00000452307 | ZNF14 | chr19 | 19843765 | - | STAT5A | chr17 | 40447637 | + |
| In-frame | ENST00000344099 | ENST00000588868 | ZNF14 | chr19 | 19843765 | - | STAT5A | chr17 | 40447637 | + |
| 5CDS-intron | ENST00000344099 | ENST00000587646 | ZNF14 | chr19 | 19843765 | - | STAT5A | chr17 | 40447637 | + |
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FusionProtFeatures for ZNF14_STAT5A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZNF14 | STAT5A |